Coronaridine, also known as 18-carbomethoxyibogamine, is an
alkaloid found in Tabernanthe iboga and related species, including Tabernaemontana divaricata for which (under the now obsolete synonym Ervatamia coronaria) it was named.[1]
Like
ibogaine, (R)-coronaridine and (S)-coronaridine can decrease intake of cocaine and morphine in animals[2] and it may have
muscle relaxant and
hypotensive activity.[3]
Chemistry
Congeners
Coronaridine congers are important in drug discovery and development due to multiple actions on different targets. They have ability to inhibit
Cav2.2 channel,[4] modulate and inhibit subunits of nAChr selectively such as α9α10,[4]α3β4[5][6] and potentiate
GABAA activity.[7]
Coronaridine, also known as 18-carbomethoxyibogamine, is an
alkaloid found in Tabernanthe iboga and related species, including Tabernaemontana divaricata for which (under the now obsolete synonym Ervatamia coronaria) it was named.[1]
Like
ibogaine, (R)-coronaridine and (S)-coronaridine can decrease intake of cocaine and morphine in animals[2] and it may have
muscle relaxant and
hypotensive activity.[3]
Chemistry
Congeners
Coronaridine congers are important in drug discovery and development due to multiple actions on different targets. They have ability to inhibit
Cav2.2 channel,[4] modulate and inhibit subunits of nAChr selectively such as α9α10,[4]α3β4[5][6] and potentiate
GABAA activity.[7]