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Formula | C25H37NO2 |
Molar mass | 383.576 g·mol−1 |
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Quadazocine (WIN-44,441) is an opioid antagonist of the benzomorphan family which is used in scientific research. [1] It acts as a silent antagonist at all three of the major opioid receptors— μ, κ, and δ, [1] [2] but with a significant preference in affinity for the μ receptor and the κ2 subtype. [3] [4] [5] As such, it has been touted as a "κ2-selective" antagonist, though this is not entirely accurate on account of its similar affinity for the μ receptor. [3] [5] As would be expected, quadazocine reverses the effects (e.g., analgesia) of opioid agonists like morphine and fentanyl in animals. [1] [6]
Clinical data | |
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CAS Number | |
PubChem CID | |
ChemSpider | |
UNII | |
CompTox Dashboard ( EPA) | |
Chemical and physical data | |
Formula | C25H37NO2 |
Molar mass | 383.576 g·mol−1 |
3D model ( JSmol) | |
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Quadazocine (WIN-44,441) is an opioid antagonist of the benzomorphan family which is used in scientific research. [1] It acts as a silent antagonist at all three of the major opioid receptors— μ, κ, and δ, [1] [2] but with a significant preference in affinity for the μ receptor and the κ2 subtype. [3] [4] [5] As such, it has been touted as a "κ2-selective" antagonist, though this is not entirely accurate on account of its similar affinity for the μ receptor. [3] [5] As would be expected, quadazocine reverses the effects (e.g., analgesia) of opioid agonists like morphine and fentanyl in animals. [1] [6]