7-Spiroindanyloxymorphone (SIOM) is a drug that is used in scientific research. It is a selective
δ-opioidagonist. It is a derivative of
oxymorphone.[1][2][3][4][5]
References
^Portoghese PS, Moe ST, Takemori AE (August 1993). "A selective delta 1 opioid receptor agonist derived from oxymorphone. Evidence for separate recognition sites for delta 1 opioid receptor agonists and antagonists". Journal of Medicinal Chemistry. 36 (17): 2572–4.
doi:
10.1021/jm00069a017.
PMID8394935.
^Fang X, Larson DL, Portoghese PS (September 1997). "7-spirobenzocyclohexyl derivatives of naltrexone, oxymorphone, and hydromorphone as selective opioid receptor ligands". Journal of Medicinal Chemistry. 40 (19): 3064–70.
doi:
10.1021/jm970283e.
PMID9301669.
^Ohkawa S, DiGiacomo B, Larson DL, Takemori AE, Portoghese PS (May 1997). "7-Spiroindanyl derivatives of naltrexone and oxymorphone as selective ligands for delta opioid receptors". Journal of Medicinal Chemistry. 40 (11): 1720–5.
doi:
10.1021/jm9700880.
PMID9171881.
^Kshirsagar TA, Fang X, Portoghese PS (July 1998). "14-Desoxy analogues of naltrindole and 7-spiroindanyloxymorphone: the role of the 14-hydroxy group at delta opioid receptors". Journal of Medicinal Chemistry. 41 (14): 2657–60.
doi:
10.1021/jm980209b.
PMID9651172.
7-Spiroindanyloxymorphone (SIOM) is a drug that is used in scientific research. It is a selective
δ-opioidagonist. It is a derivative of
oxymorphone.[1][2][3][4][5]
References
^Portoghese PS, Moe ST, Takemori AE (August 1993). "A selective delta 1 opioid receptor agonist derived from oxymorphone. Evidence for separate recognition sites for delta 1 opioid receptor agonists and antagonists". Journal of Medicinal Chemistry. 36 (17): 2572–4.
doi:
10.1021/jm00069a017.
PMID8394935.
^Fang X, Larson DL, Portoghese PS (September 1997). "7-spirobenzocyclohexyl derivatives of naltrexone, oxymorphone, and hydromorphone as selective opioid receptor ligands". Journal of Medicinal Chemistry. 40 (19): 3064–70.
doi:
10.1021/jm970283e.
PMID9301669.
^Ohkawa S, DiGiacomo B, Larson DL, Takemori AE, Portoghese PS (May 1997). "7-Spiroindanyl derivatives of naltrexone and oxymorphone as selective ligands for delta opioid receptors". Journal of Medicinal Chemistry. 40 (11): 1720–5.
doi:
10.1021/jm9700880.
PMID9171881.
^Kshirsagar TA, Fang X, Portoghese PS (July 1998). "14-Desoxy analogues of naltrindole and 7-spiroindanyloxymorphone: the role of the 14-hydroxy group at delta opioid receptors". Journal of Medicinal Chemistry. 41 (14): 2657–60.
doi:
10.1021/jm980209b.
PMID9651172.