From Wikipedia, the free encyclopedia
Opioid analgesic
Eptazocine
Routes of administration Oral
ATC code
Legal status
In general: ℞ (Prescription only)
(1S ,6S )-1,4-dimethyl-2,3,4,5,6,7-hexahydro-1H -1,6-methano-4-benzazonin-10-ol
CAS Number
PubChem
CID
ChemSpider
UNII
ChEMBL
Formula C 15 H 21 N O
Molar mass 231.339 g·mol−1 3D model (
JSmol )
Oc1ccc2c(c1)[C@@]3(CCN(C[C@H](C2)C3)C)C
InChI=1S/C15H21NO/c1-15-5-6-16(2)10-11(9-15)7-12-3-4-13(17)8-14(12)15/h3-4,8,11,17H,5-7,9-10H2,1-2H3/t11-,15-/m1/s1
Key:ZOWQTJXNFTWSCS-IAQYHMDHSA-N
Eptazocine (Sedapain ) is an
opioid
analgesic which was introduced in
Japan by
Morishita in 1987.
[1]
[2]
[3]
[4] It acts as a mixed
κ-opioid receptor
agonist and
μ-opioid receptor
antagonist .
[4]
[5]
[6]
See also
References
^
Index nominum 2000: international drug directory . Taylor & Francis US. 2000. p. 396.
ISBN
978-3-88763-075-1 . Retrieved 29 November 2011 .
^ American Chemical Society. Division of Medicinal Chemistry (1990).
"Cumulative NCE Introduction index, 1983-189, by Indication" . In Bristol JA (ed.). Annual Reports in Medicinal Chemistry . Academic Press. p. 381.
ISBN
978-0-12-040525-1 . Retrieved 29 November 2011 .
^ Nabeshima T, Matsuno K, Kamei H, Kameyama T (May 1985). "The interaction of eptazocine, a novel analgesic, with opioid receptors". Research Communications in Chemical Pathology and Pharmacology . 48 (2): 173–181.
PMID
2992058 .
^
a
b Nagase H, Fujii H (21 January 2011).
"Synthesis of Novel Basic Skeletons Derived from Naltrexone" . In Nagase H, Calderon SN (eds.). Chemistry of Opioids . Springer. p. 280.
ISBN
978-3-642-18106-1 . Retrieved 29 November 2011 .
^ Tamura T, Ogawa J, Taniguchi T, Waki I (January 1990).
"[Preferential action of eptazocine, a novel analgesic, with opioid receptors in isolated guinea pig ileum and mouse vas deferens preparations]" . Nihon Yakurigaku Zasshi. Folia Pharmacologica Japonica (in Japanese). 95 (1): 41–46.
doi :
10.1254/fpj.95.1_41 .
PMID
2154395 .
^ Morton IK, Hall JM (1999).
Concise dictionary of pharmacological agents: properties and synonyms . Springer. p. 113.
ISBN
978-0-7514-0499-9 . Retrieved 29 November 2011 .