From Wikipedia, the free encyclopedia
Chemical compound
Ethylketazocine
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Other names | ethylketocyclazocine |
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ATC code | |
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(1S,9R)-10-(cyclopropylmethyl)-1-ethyl-4-hydroxy-13-methyl-10-azatricyclo[7.3.1.02,7]trideca-2,4,6-trien-8-one
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CAS Number | |
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PubChem
CID | |
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IUPHAR/BPS | |
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ChemSpider | |
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ChEMBL | |
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CompTox Dashboard (
EPA) | |
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Formula | C19H25NO2 |
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Molar mass | 299.414 g·mol−1 |
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3D model (
JSmol) | |
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O=C2c1c(cc(O)cc1)[C@@]3(C([C@H]2N(CC3)CC4CC4)C)CC
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InChI=1S/C19H25NO2/c1-3-19-8-9-20(11-13-4-5-13)17(12(19)2)18(22)15-7-6-14(21)10-16(15)19/h6-7,10,12-13,17,21H,3-5,8-9,11H2,1-2H3/t12?,17-,19+/m1/s1 Key:SEJUQQOPVAUETF-MKFRLIFGSA-N
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Ethylketazocine (WIN-35,197-2), is an
opioid
drug of the
benzomorphan family which has been used extensively in
scientific research in the last few decades as a tool to aid in the study of the
κ-opioid receptor.
[1] However, due to its relatively poor
selectivity for the κ-opioid receptor over the
μ- and
δ-opioid receptors (of which it has approximately 80% and 20% of the
affinity for, respectively, in comparison), as well as its relatively poor
intrinsic activity at all sites (i.e., acts as a
partial agonist with mixed
agonist and
antagonist properties), it has been mostly replaced in recent times by newer and more
potent and selective compounds like
U-50,488 and
ICI-199,441.
[1]
[2]
[3]
See also
References