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Chemical and physical data | |
Formula | C21H27N3 |
Molar mass | 321.468 g·mol−1 |
3D model ( JSmol) | |
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(what is this?) (verify) |
Rimcazole is an antagonist [1] of the sigma receptor [2] as well as a dopamine reuptake inhibitor. [3] Sigma receptors are thought to be involved in the drug psychosis that can be induced by some drugs such as phencyclidine and cocaine, and rimcazole was originally researched as a potential antipsychotic with a different mechanism of action to traditional antipsychotic drugs. Trials proved inconclusive and rimcazole was not pursued for this application, but other sigma antagonists continue to be researched for a variety of potential applications. [4] Rimcazole has been shown to reduce the effects of cocaine, [5] and analogues of rimcazole have been shown to be highly effective at blocking the convulsions caused by cocaine overdose in animal models. [6]
Clinical data | |
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ATC code |
|
Identifiers | |
| |
CAS Number | |
PubChem CID | |
ChemSpider | |
UNII | |
ChEMBL | |
CompTox Dashboard ( EPA) | |
Chemical and physical data | |
Formula | C21H27N3 |
Molar mass | 321.468 g·mol−1 |
3D model ( JSmol) | |
| |
| |
(what is this?) (verify) |
Rimcazole is an antagonist [1] of the sigma receptor [2] as well as a dopamine reuptake inhibitor. [3] Sigma receptors are thought to be involved in the drug psychosis that can be induced by some drugs such as phencyclidine and cocaine, and rimcazole was originally researched as a potential antipsychotic with a different mechanism of action to traditional antipsychotic drugs. Trials proved inconclusive and rimcazole was not pursued for this application, but other sigma antagonists continue to be researched for a variety of potential applications. [4] Rimcazole has been shown to reduce the effects of cocaine, [5] and analogues of rimcazole have been shown to be highly effective at blocking the convulsions caused by cocaine overdose in animal models. [6]