Identifiers | |
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CAS Number | |
PubChem CID | |
ChemSpider | |
ChEMBL | |
CompTox Dashboard ( EPA) | |
Chemical and physical data | |
Formula | C18H19NO |
Molar mass | 265.356 g·mol−1 |
3D model ( JSmol) | |
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HP-505 is a triple reuptake inhibitor that was investigated by Hoechst-Roussel Pharmaceuticals. [1] In mice, HP-505 was a potent inhibitor of tetrabenazine-induced ptosis which may indicate antidepressant activity. [2]
5-HT | NE | DA | NE:5-HT | DA:5-HT |
---|---|---|---|---|
0.19 ± 0.04 | 0.34 ± 0.1 | 0.66 ± 0.15 | 1.8 | 3.5 |
The inhibitory effect of HP-505 on serotonin reuptake is approximately 1.8 and 3.5 times stronger than on norepinephrine and dopamine, respectively. [1] Subsequent investigations have found that HP-505 acts on presynaptic dopamine transporters and is devoid of anticholinergic effects. [3]
The N-methylated analog is called HP-365 [59142-29-9].
An older synthesis is available, although more modern methods exist now: [4]
Identifiers | |
---|---|
| |
CAS Number | |
PubChem CID | |
ChemSpider | |
ChEMBL | |
CompTox Dashboard ( EPA) | |
Chemical and physical data | |
Formula | C18H19NO |
Molar mass | 265.356 g·mol−1 |
3D model ( JSmol) | |
| |
|
HP-505 is a triple reuptake inhibitor that was investigated by Hoechst-Roussel Pharmaceuticals. [1] In mice, HP-505 was a potent inhibitor of tetrabenazine-induced ptosis which may indicate antidepressant activity. [2]
5-HT | NE | DA | NE:5-HT | DA:5-HT |
---|---|---|---|---|
0.19 ± 0.04 | 0.34 ± 0.1 | 0.66 ± 0.15 | 1.8 | 3.5 |
The inhibitory effect of HP-505 on serotonin reuptake is approximately 1.8 and 3.5 times stronger than on norepinephrine and dopamine, respectively. [1] Subsequent investigations have found that HP-505 acts on presynaptic dopamine transporters and is devoid of anticholinergic effects. [3]
The N-methylated analog is called HP-365 [59142-29-9].
An older synthesis is available, although more modern methods exist now: [4]