From Wikipedia, the free encyclopedia
Chemical compound
Pridefine (AHR-1,118) is a
drug which was investigated as an
antidepressant in the late 1970s and early 1980s, but was never marketed.
[1] It acts as a balanced
reuptake inhibitor of
serotonin,
dopamine, and
norepinephrine, and also has some weak
releasing activity.
[1]
[2]
[3]
In
clinical trials pridefine was found to be as efficacious as the
tricyclic antidepressants
amitriptyline and
imipramine in the treatment of
major depressive disorder but was much more
tolerable in comparison and also had an earlier
onset of action.
[1] It has been shown to be effective in the treatment of
alcoholism as well.
[1]
See also
References
|
---|
|
---|
SSRIsTooltip Selective serotonin reuptake inhibitors | |
---|
SNRIsTooltip Serotonin–norepinephrine reuptake inhibitors | |
---|
NRIsTooltip Norepinephrine reuptake inhibitors | |
---|
NDRIsTooltip Norepinephrine–dopamine reuptake inhibitors | |
---|
NaSSAsTooltip Noradrenergic and specific serotonergic antidepressants | |
---|
SARIsTooltip Serotonin antagonist and reuptake inhibitors | |
---|
SMSTooltip Serotonin modulator and stimulators | |
---|
Others | |
---|
|
|
|
---|
TCAsTooltip Tricyclic antidepressants | |
---|
TeCAsTooltip Tetracyclic antidepressants | |
---|
Others | |
---|
|
|
|
---|
Non-selective | |
---|
MAOATooltip Monoamine oxidase A-selective | |
---|
MAOBTooltip Monoamine oxidase B-selective | |
---|
|
|
|
|
|
|
---|
DATTooltip Dopamine transporter (
DRIsTooltip Dopamine reuptake inhibitors) | |
---|
NETTooltip Norepinephrine transporter (
NRIsTooltip Norepinephrine reuptake inhibitors) | | | | | | |
- Others:
Antihistamines (e.g.,
brompheniramine,
chlorphenamine,
pheniramine,
tripelennamine)
-
Antipsychotics (e.g.,
loxapine,
ziprasidone)
-
Arylcyclohexylamines (e.g.,
ketamine,
phencyclidine)
-
Dopexamine
-
Ephenidine
-
Ginkgo biloba
-
Indeloxazine
-
Nefazodone
-
Opioids (e.g.,
desmetramadol,
methadone,
pethidine (meperidine),
tapentadol,
tramadol,
levorphanol)
|
|
---|
SERTTooltip Serotonin transporter (
SRIsTooltip Serotonin reuptake inhibitors) | | | | |
- Others:
A-80426
-
Amoxapine
-
Antihistamines (e.g.,
brompheniramine,
chlorphenamine,
dimenhydrinate,
diphenhydramine,
mepyramine (pyrilamine),
pheniramine,
tripelennamine)
-
Antipsychotics (e.g.,
loxapine,
ziprasidone)
-
Arylcyclohexylamines (e.g.,
3-MeO-PCP,
esketamine,
ketamine,
methoxetamine,
phencyclidine)
-
Cyclobenzaprine
-
Delucemine
-
Dextromethorphan
-
Dextrorphan
-
Efavirenz
-
Hypidone
-
Medifoxamine
-
Mesembrine
-
Mifepristone
-
MIN-117 (WF-516)
-
N-Me-5-HT
-
Opioids (e.g.,
dextropropoxyphene,
methadone,
pethidine (meperidine),
levorphanol,
tapentadol,
tramadol)
-
Roxindole
|
|
---|
VMATsTooltip Vesicular monoamine transporters | |
---|
Others | |
---|
|
|
---|
DRAsTooltip Dopamine releasing agents | |
---|
NRAsTooltip Norepinephrine releasing agents | |
---|
SRAsTooltip Serotonin releasing agents | |
---|
Others | |
---|
|