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Clinical data | |
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AHFS/ Drugs.com | International Drug Names |
Routes of administration | Oral |
ATC code | |
Legal status | |
Legal status | |
Pharmacokinetic data | |
Elimination half-life | 2-2.5 hours |
Identifiers | |
| |
CAS Number | |
PubChem CID | |
ChemSpider | |
UNII | |
KEGG | |
ChEMBL | |
CompTox Dashboard ( EPA) | |
ECHA InfoCard | 100.043.012 |
Chemical and physical data | |
Formula | C17H22N4O |
Molar mass | 298.390 g·mol−1 |
3D model ( JSmol) | |
| |
(what is this?) (verify) |
Minaprine ( INN, USAN, BAN; brand names Brantur, Cantor) is a monoamine oxidase inhibitor antidepressant drug [2] that was used in France for the treatment of depression until it was withdrawn from the market in 1996 because it caused convulsions. [3]
A study found that it acts as a reversible inhibitor of MAO-A (RIMA) in rats. [4] It has also been found to weakly inhibit acetylcholinesterase in rat brain (striatum) homogenates. [5]
It has demonstrated significant antibiotic activity against M. chelonae and M. abscessus in tests with antibiotic resistant bacteria. [6]
Minaprine is a member of pyridazines, a secondary amine and a member of morpholines. It has a role as an antidepressant, a serotonin uptake inhibitor, a dopamine uptake inhibitor, a cholinergic drug and an antiparkinson drug. [7]
This article has multiple issues. Please help
improve it or discuss these issues on the
talk page. (
Learn how and when to remove these template messages)
|
Clinical data | |
---|---|
AHFS/ Drugs.com | International Drug Names |
Routes of administration | Oral |
ATC code | |
Legal status | |
Legal status | |
Pharmacokinetic data | |
Elimination half-life | 2-2.5 hours |
Identifiers | |
| |
CAS Number | |
PubChem CID | |
ChemSpider | |
UNII | |
KEGG | |
ChEMBL | |
CompTox Dashboard ( EPA) | |
ECHA InfoCard | 100.043.012 |
Chemical and physical data | |
Formula | C17H22N4O |
Molar mass | 298.390 g·mol−1 |
3D model ( JSmol) | |
| |
(what is this?) (verify) |
Minaprine ( INN, USAN, BAN; brand names Brantur, Cantor) is a monoamine oxidase inhibitor antidepressant drug [2] that was used in France for the treatment of depression until it was withdrawn from the market in 1996 because it caused convulsions. [3]
A study found that it acts as a reversible inhibitor of MAO-A (RIMA) in rats. [4] It has also been found to weakly inhibit acetylcholinesterase in rat brain (striatum) homogenates. [5]
It has demonstrated significant antibiotic activity against M. chelonae and M. abscessus in tests with antibiotic resistant bacteria. [6]
Minaprine is a member of pyridazines, a secondary amine and a member of morpholines. It has a role as an antidepressant, a serotonin uptake inhibitor, a dopamine uptake inhibitor, a cholinergic drug and an antiparkinson drug. [7]