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Chemical compound
Tetrindole
ATC code
2,3,3a,4,5,6-Hexahydro-8-cyclohexyl-1H -pyrazino[3,2,1-j,k]carbazole
PubChem
CID
ChemSpider
ChEBI
Formula C 20 H 26 N 2
Molar mass 294.442 g·mol−1 3D model (
JSmol )
C1CCC(CC1)C2=CC3=C(C=C2)N4CCNC5C4=C3CCC5
InChI=1S/C20H26N2/c1-2-5-14(6-3-1)15-9-10-19-17(13-15)16-7-4-8-18-20(16)22(19)12-11-21-18/h9-10,13-14,18,21H,1-8,11-12H2
Y Key:AUXCHYJDVJZEPG-UHFFFAOYSA-N
Y
N Y
(what is this?)
(verify)
Tetrindole was a drug candidate that functions by
reversibly inhibiting
monoamine oxidase A ; it was first synthesized in Moscow in the early 1990s.
[1] Tetrindole is similar in its chemical structure to
pirlindole (Pyrazidol), and
metralindole .
[2]
References
^ Medvedev AE, Kirkel AA, Kamyshanskaya NS, Moskvitina TA, Axenova LN, Gorkin VZ, et al. (January 1994). "Monoamine oxidase inhibition by novel antidepressant tetrindole". Biochemical Pharmacology . 47 (2): 303–8.
doi :
10.1016/0006-2952(94)90021-3 .
PMID
8304974 .
^ Ramsay RR, Gravestock MB (March 2003). "Monoamine oxidases: to inhibit or not to inhibit". Mini Reviews in Medicinal Chemistry . 3 (2): 129–36.
doi :
10.2174/1389557033405287 .
PMID
12570845 .
SSRIs Tooltip Selective serotonin reuptake inhibitors
SNRIs Tooltip Serotonin–norepinephrine reuptake inhibitors
NRIs Tooltip Norepinephrine reuptake inhibitors
NDRIs Tooltip Norepinephrine–dopamine reuptake inhibitors
NaSSAs Tooltip Noradrenergic and specific serotonergic antidepressants
SARIs Tooltip Serotonin antagonist and reuptake inhibitors
SMS Tooltip Serotonin modulator and stimulators Others
TCAs Tooltip Tricyclic antidepressants
TeCAs Tooltip Tetracyclic antidepressants Others
Non-selective
MAOA Tooltip Monoamine oxidase A -selective
MAOB Tooltip Monoamine oxidase B -selective