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Chemical and physical data | |
Formula | C13H15Cl2NO |
Molar mass | 272.17 g·mol−1 |
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(what is this?) (verify) |
Clorgiline ( INN), or clorgyline ( BAN), is a monoamine oxidase inhibitor (MAOI) structurally related to pargyline which is described as an antidepressant. [1] [2] Specifically, it is an irreversible and selective inhibitor of monoamine oxidase A (MAO-A). [3] Clorgiline was never marketed, [1] but it has found use in scientific research. [4] It has been found to bind with high affinity to the σ1 receptor (Ki = 3.2 nM) [3] [5] and with very high affinity to the I2 imidazoline receptor (Ki = 40 pM). [6]
Clorgiline is also a multidrug efflux pump inhibitor. [7] Holmes et al., 2012 reverse azole fungicide resistance using clorgiline, showing promise for its use in multiple fungicide resistance. [7]
Clinical data | |
---|---|
ATC code |
|
Legal status | |
Legal status |
|
Identifiers | |
| |
CAS Number | |
PubChem CID | |
IUPHAR/BPS | |
DrugBank | |
ChemSpider | |
UNII | |
KEGG | |
ChEBI | |
ChEMBL | |
CompTox Dashboard ( EPA) | |
Chemical and physical data | |
Formula | C13H15Cl2NO |
Molar mass | 272.17 g·mol−1 |
3D model ( JSmol) | |
| |
| |
(what is this?) (verify) |
Clorgiline ( INN), or clorgyline ( BAN), is a monoamine oxidase inhibitor (MAOI) structurally related to pargyline which is described as an antidepressant. [1] [2] Specifically, it is an irreversible and selective inhibitor of monoamine oxidase A (MAO-A). [3] Clorgiline was never marketed, [1] but it has found use in scientific research. [4] It has been found to bind with high affinity to the σ1 receptor (Ki = 3.2 nM) [3] [5] and with very high affinity to the I2 imidazoline receptor (Ki = 40 pM). [6]
Clorgiline is also a multidrug efflux pump inhibitor. [7] Holmes et al., 2012 reverse azole fungicide resistance using clorgiline, showing promise for its use in multiple fungicide resistance. [7]