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| ATC code |
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| Identifiers | |
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| PubChem CID | |
| IUPHAR/BPS | |
| ChemSpider | |
| UNII | |
| ChEMBL | |
| CompTox Dashboard ( EPA) | |
| ECHA InfoCard | 100.002.344 |
| Chemical and physical data | |
| Formula | C15H17N3 |
| Molar mass | 239.322 g·mol−1 |
| 3D model ( JSmol) | |
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| (verify) | |
Ditolylguanidine is a sigma receptor agonist. [1] It is somewhat [2] selective for sigma receptors, but non-selective between the two sigma receptor subtypes, binding to both σ1 and σ2 with equal affinity. [3] It has neuroprotective [4] and antidepressant effects, [5] and potentiates the effects of NMDA antagonists. [6]
See also
References
- ^ Weber E, Sonders M, Quarum M, McLean S, Pou S, Keana JF (November 1986). "1,3-Di(2-[5-3H]tolyl)guanidine: a selective ligand that labels sigma-type receptors for psychotomimetic opiates and antipsychotic drugs". Proceedings of the National Academy of Sciences of the United States of America. 83 (22): 8784–8788. Bibcode: 1986PNAS...83.8784W. doi: 10.1073/pnas.83.22.8784. PMC 387016. PMID 2877462.
- ^ "1,3-Di-o-tolylguanidine | C15H17N3". PubChem. U.S. National Library of Medicine. Archived from the original on 2021-01-08. Retrieved 2017-06-07.
- ^ Glennon RA (October 2005). "Pharmacophore identification for sigma-1 (sigma1) receptor binding: application of the "deconstruction-reconstruction-elaboration" approach". Mini Reviews in Medicinal Chemistry. 5 (10): 927–940. doi: 10.2174/138955705774329519. PMID 16250835.
- ^ Katnik C, Guerrero WR, Pennypacker KR, Herrera Y, Cuevas J (December 2006). "Sigma-1 receptor activation prevents intracellular calcium dysregulation in cortical neurons during in vitro ischemia". The Journal of Pharmacology and Experimental Therapeutics. 319 (3): 1355–1365. doi: 10.1124/jpet.106.107557. PMID 16988055. S2CID 14582181.
- ^ Skuza G, Rogóz Z (2003). "Sigma1 receptor antagonists attenuate antidepressant-like effect induced by co-administration of 1,3 di-o-tolylguanidine (DTG) and memantine in the forced swimming test in rats". Polish Journal of Pharmacology. 55 (6): 1149–1152. PMID 14730114.
- ^ Monnet FP, Morin-Surun MP, Leger J, Combettes L (November 2003). "Protein kinase C-dependent potentiation of intracellular calcium influx by sigma1 receptor agonists in rat hippocampal neurons". The Journal of Pharmacology and Experimental Therapeutics. 307 (2): 705–712. doi: 10.1124/jpet.103.053447. PMID 12975497. S2CID 35397107.
 | This drug article relating to the nervous system is a stub. You can help Wikipedia by expanding it. |
|
| |
|
| |
| Clinical data | |
|---|---|
| ATC code |
|
| Identifiers | |
| |
| CAS Number | |
| PubChem CID | |
| IUPHAR/BPS | |
| ChemSpider | |
| UNII | |
| ChEMBL | |
| CompTox Dashboard ( EPA) | |
| ECHA InfoCard | 100.002.344 |
| Chemical and physical data | |
| Formula | C15H17N3 |
| Molar mass | 239.322 g·mol−1 |
| 3D model ( JSmol) | |
| |
| |
| (verify) | |
Ditolylguanidine is a sigma receptor agonist. [1] It is somewhat [2] selective for sigma receptors, but non-selective between the two sigma receptor subtypes, binding to both σ1 and σ2 with equal affinity. [3] It has neuroprotective [4] and antidepressant effects, [5] and potentiates the effects of NMDA antagonists. [6]
See also
References
- ^ Weber E, Sonders M, Quarum M, McLean S, Pou S, Keana JF (November 1986). "1,3-Di(2-[5-3H]tolyl)guanidine: a selective ligand that labels sigma-type receptors for psychotomimetic opiates and antipsychotic drugs". Proceedings of the National Academy of Sciences of the United States of America. 83 (22): 8784–8788. Bibcode: 1986PNAS...83.8784W. doi: 10.1073/pnas.83.22.8784. PMC 387016. PMID 2877462.
- ^ "1,3-Di-o-tolylguanidine | C15H17N3". PubChem. U.S. National Library of Medicine. Archived from the original on 2021-01-08. Retrieved 2017-06-07.
- ^ Glennon RA (October 2005). "Pharmacophore identification for sigma-1 (sigma1) receptor binding: application of the "deconstruction-reconstruction-elaboration" approach". Mini Reviews in Medicinal Chemistry. 5 (10): 927–940. doi: 10.2174/138955705774329519. PMID 16250835.
- ^ Katnik C, Guerrero WR, Pennypacker KR, Herrera Y, Cuevas J (December 2006). "Sigma-1 receptor activation prevents intracellular calcium dysregulation in cortical neurons during in vitro ischemia". The Journal of Pharmacology and Experimental Therapeutics. 319 (3): 1355–1365. doi: 10.1124/jpet.106.107557. PMID 16988055. S2CID 14582181.
- ^ Skuza G, Rogóz Z (2003). "Sigma1 receptor antagonists attenuate antidepressant-like effect induced by co-administration of 1,3 di-o-tolylguanidine (DTG) and memantine in the forced swimming test in rats". Polish Journal of Pharmacology. 55 (6): 1149–1152. PMID 14730114.
- ^ Monnet FP, Morin-Surun MP, Leger J, Combettes L (November 2003). "Protein kinase C-dependent potentiation of intracellular calcium influx by sigma1 receptor agonists in rat hippocampal neurons". The Journal of Pharmacology and Experimental Therapeutics. 307 (2): 705–712. doi: 10.1124/jpet.103.053447. PMID 12975497. S2CID 35397107.
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| This drug article relating to the nervous system is a stub. You can help Wikipedia by expanding it. |