2β-Propanoyl-3β-(4-tolyl)tropane also known as WF-11 or 2-PTT is a
cocaineanalogue 20 times more potent than cocaine at binding to the dopamine transporter with increased selectivity for the norepinephrine transporters. It also shows marked increase in metabolic stability. In contrast to the findings of cocaine effects, WF-11 has been shown to produce a uniform
downregulation of
tyrosine hydroxylase protein and activity
gene expression with a regimen of use.[1]
2β-Propanoyl-3β-(4-tolyl)tropane also known as WF-11 or 2-PTT is a
cocaineanalogue 20 times more potent than cocaine at binding to the dopamine transporter with increased selectivity for the norepinephrine transporters. It also shows marked increase in metabolic stability. In contrast to the findings of cocaine effects, WF-11 has been shown to produce a uniform
downregulation of
tyrosine hydroxylase protein and activity
gene expression with a regimen of use.[1]