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CompTox Dashboard ( EPA) | |
Chemical and physical data | |
Formula | C17H19N |
Molar mass | 237.346 g·mol−1 |
3D model ( JSmol) | |
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(what is this?) (verify) |
Tametraline (CP-24,441) is the parent of a series of chemical compounds investigated at Pfizer that eventually led to the development of sertraline (CP-51,974-1). [1]
Sertraline has been called "3,4-dichloro-tametraline". This is correct but it is an oversimplification in the sense that sertraline is the S,S-isomer whereas tametraline is the 1R,4S-stereoisomer.
1R-Methylamino-4S-phenyl- tetralin is a potent inhibitor of norepinephrine uptake in rat brain synaptosomes, [2] reverses reserpine induced hypothermia in mice, and blocks uptake of 3H- Norepinephrine into rat heart. [3]
Tametraline is a norepinephrine-dopamine reuptake inhibitor. [4]
Indatraline is an indanamine homolog of tetralin-based tametraline, although in the case of indatraline the product is pm-dichlorinated.
Tametraline is completely unscheduled.
Clinical data | |
---|---|
ATC code |
|
Identifiers | |
| |
CAS Number |
|
PubChem CID | |
ChemSpider | |
UNII |
|
CompTox Dashboard ( EPA) | |
Chemical and physical data | |
Formula | C17H19N |
Molar mass | 237.346 g·mol−1 |
3D model ( JSmol) | |
| |
| |
(what is this?) (verify) |
Tametraline (CP-24,441) is the parent of a series of chemical compounds investigated at Pfizer that eventually led to the development of sertraline (CP-51,974-1). [1]
Sertraline has been called "3,4-dichloro-tametraline". This is correct but it is an oversimplification in the sense that sertraline is the S,S-isomer whereas tametraline is the 1R,4S-stereoisomer.
1R-Methylamino-4S-phenyl- tetralin is a potent inhibitor of norepinephrine uptake in rat brain synaptosomes, [2] reverses reserpine induced hypothermia in mice, and blocks uptake of 3H- Norepinephrine into rat heart. [3]
Tametraline is a norepinephrine-dopamine reuptake inhibitor. [4]
Indatraline is an indanamine homolog of tetralin-based tametraline, although in the case of indatraline the product is pm-dichlorinated.
Tametraline is completely unscheduled.