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Clinical data | |
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ChemSpider | |
UNII | |
CompTox Dashboard ( EPA) | |
Chemical and physical data | |
Formula | C15H17Cl2NO2 |
Molar mass | 314.21 g·mol−1 |
3D model ( JSmol) | |
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(what is this?) (verify) |
Dichloropane ((−)-2β-Carbomethoxy-3β-(3,4-dichlorophenyl)tropane, RTI-111, O-401) is a stimulant of the phenyltropane class that acts as a serotonin–norepinephrine–dopamine reuptake inhibitor (SNDRI) with IC50 values of 3.13, 18, and 0.79 nM, respectively. [1] In animal studies, dichloropane had a slower onset and longer duration of action compared to cocaine. [2] [3]
Methylecgonidine is the direct precursor to this compound. [4]
The thermodynamic isomer with a trans -CO2Me group is still active. This isomer was used by Neurosearch to make three different phenyltropanes which were tested in clinical trials.
This article has multiple issues. Please help
improve it or discuss these issues on the
talk page. (
Learn how and when to remove these template messages)
|
Clinical data | |
---|---|
ATC code |
|
Legal status | |
Legal status |
|
Identifiers | |
| |
CAS Number | |
PubChem CID | |
ChemSpider | |
UNII | |
CompTox Dashboard ( EPA) | |
Chemical and physical data | |
Formula | C15H17Cl2NO2 |
Molar mass | 314.21 g·mol−1 |
3D model ( JSmol) | |
| |
| |
(what is this?) (verify) |
Dichloropane ((−)-2β-Carbomethoxy-3β-(3,4-dichlorophenyl)tropane, RTI-111, O-401) is a stimulant of the phenyltropane class that acts as a serotonin–norepinephrine–dopamine reuptake inhibitor (SNDRI) with IC50 values of 3.13, 18, and 0.79 nM, respectively. [1] In animal studies, dichloropane had a slower onset and longer duration of action compared to cocaine. [2] [3]
Methylecgonidine is the direct precursor to this compound. [4]
The thermodynamic isomer with a trans -CO2Me group is still active. This isomer was used by Neurosearch to make three different phenyltropanes which were tested in clinical trials.