Clinical data | |
---|---|
ATC code |
|
Identifiers | |
| |
CAS Number | |
PubChem CID | |
UNII | |
CompTox Dashboard ( EPA) | |
Chemical and physical data | |
Formula | C18H29NO |
Molar mass | 275.436 g·mol−1 |
3D model ( JSmol) | |
| |
(verify) |
UH-232 ((+)-UH232) is a drug which acts as a subtype selective mixed agonist-antagonist for dopamine receptors, acting as a weak partial agonist at the D3 subtype, [1] and an antagonist at D2Sh autoreceptors on dopaminergic nerve terminals. [2] [3] [4] It causes dopamine release in the brain and has a stimulant effect, [5] [6] [7] as well as blocking the behavioural effects of cocaine. [8] It may also serve as a 5-HT2A receptor agonist, based on animal studies. [9] It was investigated in clinical trials for the treatment of schizophrenia, but unexpectedly caused symptoms to become worse. [9]
The N-monopropyl derivative (+)-AJ76 is an active metabolite of UH-232 and has practically identical effects.
Clinical data | |
---|---|
ATC code |
|
Identifiers | |
| |
CAS Number | |
PubChem CID | |
UNII | |
CompTox Dashboard ( EPA) | |
Chemical and physical data | |
Formula | C18H29NO |
Molar mass | 275.436 g·mol−1 |
3D model ( JSmol) | |
| |
(verify) |
UH-232 ((+)-UH232) is a drug which acts as a subtype selective mixed agonist-antagonist for dopamine receptors, acting as a weak partial agonist at the D3 subtype, [1] and an antagonist at D2Sh autoreceptors on dopaminergic nerve terminals. [2] [3] [4] It causes dopamine release in the brain and has a stimulant effect, [5] [6] [7] as well as blocking the behavioural effects of cocaine. [8] It may also serve as a 5-HT2A receptor agonist, based on animal studies. [9] It was investigated in clinical trials for the treatment of schizophrenia, but unexpectedly caused symptoms to become worse. [9]
The N-monopropyl derivative (+)-AJ76 is an active metabolite of UH-232 and has practically identical effects.