Alimemazine (
INN), also known as trimeprazine, (brand names Nedeltran, Panectyl, Repeltin, Therafene, Theraligene, Theralen, Thegalin, Theralene, Vallergan, Vanectyl, and Temaril), commonly provided as a
tartrate salt, is a
phenothiazine derivative that is used as an
antipruritic (it prevents itching from causes such as
eczema or
poison ivy, by acting as an
antihistamine).[2] It also acts as a
sedative,
hypnotic, and
antiemetic for prevention of
motion sickness. Although it is structurally related to drugs such as
chlorpromazine, it is not used as an
antipsychotic.[3] In the Russian Federation, it is marketed under the brand name Teraligen for the treatment of anxiety disorders (including
GAD), organic mood disorders, sleep disturbances, personality disorders accompanied by asthenia and depression,
somatoformautonomic dysfunction and various
neuroses.[4]
Alimemazine is not approved for use in humans in the United States. The combination of alimemazine and
prednisolone (commonly sold under the brand name Temaril-P) is licensed as an antipruritic and
antitussive in dogs.
References
^Hu OY, Gfeller E, Perrin JH, Curry SH (March 1986). "Relative bioavailability of trimeprazine tablets investigated in man using HPLC with electrochemical detection". The Journal of Pharmacy and Pharmacology. 38 (3): 172–6.
doi:
10.1111/j.2042-7158.1986.tb04539.x.
PMID2871150.
S2CID506087.
Alimemazine (
INN), also known as trimeprazine, (brand names Nedeltran, Panectyl, Repeltin, Therafene, Theraligene, Theralen, Thegalin, Theralene, Vallergan, Vanectyl, and Temaril), commonly provided as a
tartrate salt, is a
phenothiazine derivative that is used as an
antipruritic (it prevents itching from causes such as
eczema or
poison ivy, by acting as an
antihistamine).[2] It also acts as a
sedative,
hypnotic, and
antiemetic for prevention of
motion sickness. Although it is structurally related to drugs such as
chlorpromazine, it is not used as an
antipsychotic.[3] In the Russian Federation, it is marketed under the brand name Teraligen for the treatment of anxiety disorders (including
GAD), organic mood disorders, sleep disturbances, personality disorders accompanied by asthenia and depression,
somatoformautonomic dysfunction and various
neuroses.[4]
Alimemazine is not approved for use in humans in the United States. The combination of alimemazine and
prednisolone (commonly sold under the brand name Temaril-P) is licensed as an antipruritic and
antitussive in dogs.
References
^Hu OY, Gfeller E, Perrin JH, Curry SH (March 1986). "Relative bioavailability of trimeprazine tablets investigated in man using HPLC with electrochemical detection". The Journal of Pharmacy and Pharmacology. 38 (3): 172–6.
doi:
10.1111/j.2042-7158.1986.tb04539.x.
PMID2871150.
S2CID506087.