Clinical data | |
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AHFS/ Drugs.com | International Drug Names |
Routes of administration | By mouth |
ATC code | |
Legal status | |
Legal status |
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Identifiers | |
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CAS Number | |
PubChem CID | |
ChemSpider | |
UNII |
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KEGG | |
ChEMBL | |
CompTox Dashboard ( EPA) | |
ECHA InfoCard | 100.020.756 |
Chemical and physical data | |
Formula | C25H35NO5 |
Molar mass | 429.557 g·mol−1 |
3D model ( JSmol) | |
Chirality | Racemic mixture |
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(verify) |
Mebeverine is a drug used to alleviate some of the symptoms of irritable bowel syndrome. It works by relaxing the muscles in and around the gut. [1]
Mebeverine is used to alleviate some of the symptoms of irritable bowel syndrome (IBS) and related conditions; specifically stomach pain and cramps, persistent diarrhoea, and flatulence. [2]
Data from controlled clinical trials have not found a difference from placebo or statistically significant results in the global improvement of IBS. [3] [4]
It has not been tested in pregnant women nor in pregnant animals so pregnant women should not take it; it is expressed at low levels in breast milk, while no adverse effects have been reported in infants, breastfeeding women should not take this drug. [1]
Adverse effects include hypersensitivity reactions and allergic reactions, immune system disorders, skin disorders including hives, oedema and widespread rashes. [2]
Additionally, the following adverse effects have been reported: heartburn, indigestion, tiredness, diarrhoea, constipation, loss of appetite, general malaise, dizziness, insomnia, headache, and decreased pulse rate. [1]
It does not have systemic anticholinergic side effects. [2]
Mebeverine can, on highly rare occasions, cause drug-induced acute angle closure glaucoma. [5]
In a urine drug-screening test, mebeverine can affect a false positive result for amphetamines. [6]
Mebeverine is an anticholinergic but its mechanism of action is not known; it appears to work directly on smooth muscle within the gastrointestinal tract and may have an anaesthetic effect, may affect calcium channels, and may affect muscarinic receptors. [2]
It is metabolized mostly by esterases, and almost completely. The metabolites are excreted in urine. [2]
Mebeverine exists in two enantiomeric forms. The commercially available product is a racemic mixture of them. A study in rats indicates that the two have different pharmacokinetic profiles. [7]
It is a second generation papaverine analog, and was first synthesized around the same time as verapamil. [8]
It was first registered in 1965. [9]
Mebeverine is a generic drug and is available internationally under many brand names such as in Bangladesh it sold as Mave and Mave SR. [10]
Clinical data | |
---|---|
AHFS/ Drugs.com | International Drug Names |
Routes of administration | By mouth |
ATC code | |
Legal status | |
Legal status |
|
Identifiers | |
| |
CAS Number | |
PubChem CID | |
ChemSpider | |
UNII |
|
KEGG | |
ChEMBL | |
CompTox Dashboard ( EPA) | |
ECHA InfoCard | 100.020.756 |
Chemical and physical data | |
Formula | C25H35NO5 |
Molar mass | 429.557 g·mol−1 |
3D model ( JSmol) | |
Chirality | Racemic mixture |
| |
| |
(verify) |
Mebeverine is a drug used to alleviate some of the symptoms of irritable bowel syndrome. It works by relaxing the muscles in and around the gut. [1]
Mebeverine is used to alleviate some of the symptoms of irritable bowel syndrome (IBS) and related conditions; specifically stomach pain and cramps, persistent diarrhoea, and flatulence. [2]
Data from controlled clinical trials have not found a difference from placebo or statistically significant results in the global improvement of IBS. [3] [4]
It has not been tested in pregnant women nor in pregnant animals so pregnant women should not take it; it is expressed at low levels in breast milk, while no adverse effects have been reported in infants, breastfeeding women should not take this drug. [1]
Adverse effects include hypersensitivity reactions and allergic reactions, immune system disorders, skin disorders including hives, oedema and widespread rashes. [2]
Additionally, the following adverse effects have been reported: heartburn, indigestion, tiredness, diarrhoea, constipation, loss of appetite, general malaise, dizziness, insomnia, headache, and decreased pulse rate. [1]
It does not have systemic anticholinergic side effects. [2]
Mebeverine can, on highly rare occasions, cause drug-induced acute angle closure glaucoma. [5]
In a urine drug-screening test, mebeverine can affect a false positive result for amphetamines. [6]
Mebeverine is an anticholinergic but its mechanism of action is not known; it appears to work directly on smooth muscle within the gastrointestinal tract and may have an anaesthetic effect, may affect calcium channels, and may affect muscarinic receptors. [2]
It is metabolized mostly by esterases, and almost completely. The metabolites are excreted in urine. [2]
Mebeverine exists in two enantiomeric forms. The commercially available product is a racemic mixture of them. A study in rats indicates that the two have different pharmacokinetic profiles. [7]
It is a second generation papaverine analog, and was first synthesized around the same time as verapamil. [8]
It was first registered in 1965. [9]
Mebeverine is a generic drug and is available internationally under many brand names such as in Bangladesh it sold as Mave and Mave SR. [10]