Clinical data | |
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Trade names | Evoxac |
AHFS/ Drugs.com | Monograph |
MedlinePlus | a608025 |
Pregnancy category |
|
Routes of administration | By mouth ( capsules) |
ATC code | |
Legal status | |
Legal status |
|
Pharmacokinetic data | |
Protein binding | <20% |
Identifiers | |
| |
CAS Number | |
PubChem CID | |
DrugBank | |
ChemSpider | |
UNII | |
KEGG | |
ChEBI | |
ChEMBL | |
CompTox Dashboard ( EPA) | |
Chemical and physical data | |
Formula | C10H17NOS |
Molar mass | 199.31 g·mol−1 |
3D model ( JSmol) | |
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(what is this?) (verify) |
Cevimeline (trade name Evoxac) is a synthetic analog of the natural alkaloid muscarine with a particular agonistic effect on M1 and M3 receptors. It is used in the treatment of dry mouth and Sjögren's syndrome.
Cevimeline is used in the treatment of xerostomia (dry mouth) [1] [2] and Sjögren's syndrome. [1] It increases the production of saliva. [2]
Known side effects include nausea, vomiting, diarrhea, excessive sweating, rash, headache, runny nose, cough, drowsiness, hot flashes, blurred vision, and difficulty sleeping. [3]
Contraindications include asthma and angle closure glaucoma.[ citation needed]
Cevimeline is a cholinergic agonist. [2] It has a particular effect on M1 and M3 receptors. [2] By activating the M3 receptors of the parasympathetic nervous system, cevimeline stimulates secretion by the salivary glands, thereby alleviating dry mouth.
Clinical data | |
---|---|
Trade names | Evoxac |
AHFS/ Drugs.com | Monograph |
MedlinePlus | a608025 |
Pregnancy category |
|
Routes of administration | By mouth ( capsules) |
ATC code | |
Legal status | |
Legal status |
|
Pharmacokinetic data | |
Protein binding | <20% |
Identifiers | |
| |
CAS Number | |
PubChem CID | |
DrugBank | |
ChemSpider | |
UNII | |
KEGG | |
ChEBI | |
ChEMBL | |
CompTox Dashboard ( EPA) | |
Chemical and physical data | |
Formula | C10H17NOS |
Molar mass | 199.31 g·mol−1 |
3D model ( JSmol) | |
| |
| |
(what is this?) (verify) |
Cevimeline (trade name Evoxac) is a synthetic analog of the natural alkaloid muscarine with a particular agonistic effect on M1 and M3 receptors. It is used in the treatment of dry mouth and Sjögren's syndrome.
Cevimeline is used in the treatment of xerostomia (dry mouth) [1] [2] and Sjögren's syndrome. [1] It increases the production of saliva. [2]
Known side effects include nausea, vomiting, diarrhea, excessive sweating, rash, headache, runny nose, cough, drowsiness, hot flashes, blurred vision, and difficulty sleeping. [3]
Contraindications include asthma and angle closure glaucoma.[ citation needed]
Cevimeline is a cholinergic agonist. [2] It has a particular effect on M1 and M3 receptors. [2] By activating the M3 receptors of the parasympathetic nervous system, cevimeline stimulates secretion by the salivary glands, thereby alleviating dry mouth.