As with dimenhydrinate, the stimulant effect of the etanautine counteracts the sedative effect from the diphenhydramine, resulting in an improved therapeutic profile.[2]
The 1:2 salt diphenhydramine diacefylline (with two molecules of acefylline to each molecule of diphenhydramine) is also used in medicine, under the brand name Nautamine.[1][3]
^Gonzalez F (August 21, 2009). "Diphenhydramine may be useful as a palliative treatment for patients dying with Parkinson's disease and tremors: a case report and discussion". The American Journal of Hospice & Palliative Care. 26 (6): 474–475.
doi:
10.1177/1049909109338937.
PMID19700649.
S2CID206633832.
As with dimenhydrinate, the stimulant effect of the etanautine counteracts the sedative effect from the diphenhydramine, resulting in an improved therapeutic profile.[2]
The 1:2 salt diphenhydramine diacefylline (with two molecules of acefylline to each molecule of diphenhydramine) is also used in medicine, under the brand name Nautamine.[1][3]
^Gonzalez F (August 21, 2009). "Diphenhydramine may be useful as a palliative treatment for patients dying with Parkinson's disease and tremors: a case report and discussion". The American Journal of Hospice & Palliative Care. 26 (6): 474–475.
doi:
10.1177/1049909109338937.
PMID19700649.
S2CID206633832.