From Wikipedia, the free encyclopedia
NNC 38-1049
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Names
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Preferred IUPAC name
1-(4-Chlorophenyl)-4-(4-cyclopentylpiperazin-1-yl)butane-1,4-dione
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Identifiers
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ChEMBL
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ChemSpider
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UNII
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InChI=1S/C19H25ClN2O2/c20-16-7-5-15(6-8-16)18(23)9-10-19(24)22-13-11-21(12-14-22)17-3-1-2-4-17/h5-8,17H,1-4,9-14H2 YKey: VPARRMQGLNFBBR-UHFFFAOYSA-N YInChI=1/C19H25ClN2O2/c20-16-7-5-15(6-8-16)18(23)9-10-19(24)22-13-11-21(12-14-22)17-3-1-2-4-17/h5-8,17H,1-4,9-14H2 Key: VPARRMQGLNFBBR-UHFFFAOYAT
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Clc1ccc(cc1)C(=O)CCC(=O)N3CCN(C2CCCC2)CC3
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Properties
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C19H25ClN2O2
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Molar mass
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348.866 g/mol
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Except where otherwise noted, data are given for materials in their
standard state (at 25 °C [77 °F], 100 kPa).
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Chemical compound
NNC 38-1049 is a
histamine antagonist selective for the
H3 subtype. It has
anorectic effects in animal studies and is being researched as a potential treatment for
obesity.
[1]
[2]
References
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^ Malmlöf K, Zaragoza F, Golozoubova V, et al. (December 2005).
"Influence of a selective histamine H3 receptor antagonist on hypothalamic neural activity, food intake and body weight". Int J Obes (Lond). 29 (12): 1402–12.
doi:
10.1038/sj.ijo.0803036.
PMID
16151415.
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^ Malmlöf K, Golozoubova V, Peschke B, Wulff BS, Refsgaard HH, Johansen PB, Cremers T, Rimvall K (Dec 2006).
"Increase of neuronal histamine in obese rats is associated with decreases in body weight and plasma triglycerides". Obesity (Silver Spring). 14 (12): 2154–62.
doi:
10.1038/oby.2006.252.
PMID
17189541.
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H1 | Agonists | |
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Antagonists |
- Others:
Atypical antipsychotics (e.g.,
aripiprazole,
asenapine,
brexpiprazole,
brilaroxazine,
clozapine,
iloperidone,
olanzapine,
paliperidone,
quetiapine,
risperidone,
ziprasidone,
zotepine)
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Phenylpiperazine
antidepressants (e.g.,
hydroxynefazodone,
nefazodone,
trazodone,
triazoledione)
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Tetracyclic antidepressants (e.g.,
amoxapine,
loxapine,
maprotiline,
mianserin,
mirtazapine,
oxaprotiline)
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Tricyclic antidepressants (e.g.,
amitriptyline,
butriptyline,
clomipramine,
desipramine,
dosulepin (dothiepin),
doxepin,
imipramine,
iprindole,
lofepramine,
nortriptyline,
protriptyline,
trimipramine)
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Typical antipsychotics (e.g.,
chlorpromazine,
flupenthixol,
fluphenazine,
loxapine,
perphenazine,
prochlorperazine,
thioridazine,
thiothixene)
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H2 | |
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H3 | |
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H4 | |
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