Antazoline is a 1st generation
antihistamine with
anticholinergic properties used to relieve
nasal congestion and in
eye drops, usually in combination with
naphazoline, to relieve the symptoms of
allergicconjunctivitis.[1] To treat allergic conjunctivitis, antazoline can be combined in a solution with
tetryzoline.[2] The drug is a
Histamine H1 receptor antagonist:[3] selectively binding to but not activating the receptor, thereby blocking the actions of endogenous
histamine and subsequently leading to the temporary relief of the negative symptoms brought on by histamine.
A large study on people 65 years old or older linked the development of
Alzheimer's disease and other forms of dementia to the "higher cumulative" use of first-generation antihistamines, due to their
anticholinergic properties.[4]
References
^Abelson MB, Allansmith MR, Friedlaender MH (August 1980). "Effects of topically applied occular decongestant and antihistamine". American Journal of Ophthalmology. 90 (2): 254–257.
doi:
10.1016/s0002-9394(14)74864-0.
PMID7425039.
Antazoline is a 1st generation
antihistamine with
anticholinergic properties used to relieve
nasal congestion and in
eye drops, usually in combination with
naphazoline, to relieve the symptoms of
allergicconjunctivitis.[1] To treat allergic conjunctivitis, antazoline can be combined in a solution with
tetryzoline.[2] The drug is a
Histamine H1 receptor antagonist:[3] selectively binding to but not activating the receptor, thereby blocking the actions of endogenous
histamine and subsequently leading to the temporary relief of the negative symptoms brought on by histamine.
A large study on people 65 years old or older linked the development of
Alzheimer's disease and other forms of dementia to the "higher cumulative" use of first-generation antihistamines, due to their
anticholinergic properties.[4]
References
^Abelson MB, Allansmith MR, Friedlaender MH (August 1980). "Effects of topically applied occular decongestant and antihistamine". American Journal of Ophthalmology. 90 (2): 254–257.
doi:
10.1016/s0002-9394(14)74864-0.
PMID7425039.