Names | |
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IUPAC name
1-[4-(1H-imidazol-5-yl)butyl]-3-methylthiourea
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Identifiers | |
3D model (
JSmol)
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ChEMBL | |
ChemSpider | |
KEGG | |
PubChem
CID
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UNII | |
CompTox Dashboard (
EPA)
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Properties | |
C9H16N4S | |
Molar mass | 212.32 g/mol |
Except where otherwise noted, data are given for materials in their
standard state (at 25 °C [77 °F], 100 kPa).
|
Burimamide is an antagonist at the H2 and H3 histamine receptors. At physiological pH, it is largely inactive as an H2 antagonist, [1] but its H3 affinity is 100x higher. It is a thiourea derivative.
Burimamide was first developed by scientists at Smith, Kline & French (SK&F; now GlaxoSmithKline) in their intent to develop a histamine antagonist for the treatment of peptic ulcers. [2] The discovery of burimamide ultimately led to the development of cimetidine (Tagamet). [2]
Names | |
---|---|
IUPAC name
1-[4-(1H-imidazol-5-yl)butyl]-3-methylthiourea
| |
Identifiers | |
3D model (
JSmol)
|
|
ChEMBL | |
ChemSpider | |
KEGG | |
PubChem
CID
|
|
UNII | |
CompTox Dashboard (
EPA)
|
|
| |
| |
Properties | |
C9H16N4S | |
Molar mass | 212.32 g/mol |
Except where otherwise noted, data are given for materials in their
standard state (at 25 °C [77 °F], 100 kPa).
|
Burimamide is an antagonist at the H2 and H3 histamine receptors. At physiological pH, it is largely inactive as an H2 antagonist, [1] but its H3 affinity is 100x higher. It is a thiourea derivative.
Burimamide was first developed by scientists at Smith, Kline & French (SK&F; now GlaxoSmithKline) in their intent to develop a histamine antagonist for the treatment of peptic ulcers. [2] The discovery of burimamide ultimately led to the development of cimetidine (Tagamet). [2]