From Wikipedia, the free encyclopedia
Monatepil
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Names
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Preferred IUPAC name
N-(6,11-Dihydrodibenzo[b,e]thiepin-11-yl)-4-[4-(4-fluorophenyl)piperazin-1-yl]butanamide
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Identifiers
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ChemSpider
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KEGG
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UNII
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InChI=1S/C28H30FN3OS/c29-22-11-13-23(14-12-22)32-18-16-31(17-19-32)15-5-10-27(33)30-28-24-7-2-1-6-21(24)20-34-26-9-4-3-8-25(26)28/h1-4,6-9,11-14,28H,5,10,15-20H2,(H,30,33) NKey: WFNRNNUZFPVBSM-UHFFFAOYSA-N NInChI=1/C28H30FN3OS/c29-22-11-13-23(14-12-22)32-18-16-31(17-19-32)15-5-10-27(33)30-28-24-7-2-1-6-21(24)20-34-26-9-4-3-8-25(26)28/h1-4,6-9,11-14,28H,5,10,15-20H2,(H,30,33) Key: WFNRNNUZFPVBSM-UHFFFAOYAJ
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C1CN(CCN1CCCC(=O)NC2C3=CC=CC=C3CSC4=CC=CC=C24)C5=CC=C(C=C5)F
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Properties
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C28H30FN3OS
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Molar mass
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475.63 g·mol−1
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Except where otherwise noted, data are given for materials in their
standard state (at 25 °C [77 °F], 100 kPa).
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Chemical compound
Monatepil is a
calcium channel blocker and
α1-adrenergic receptor
antagonist used as an
antihypertensive.
[1]
References
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Calcium |
VDCCsTooltip Voltage-dependent calcium channels | |
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Potassium |
VGKCsTooltip Voltage-gated potassium channels | |
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IRKsTooltip Inwardly rectifying potassium channel | |
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KCaTooltip Calcium-activated potassium channel | |
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K2PsTooltip Tandem pore domain potassium channel | |
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Sodium |
VGSCsTooltip Voltage-gated sodium channels | |
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ENaCTooltip Epithelial sodium channel | |
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ASICsTooltip Acid-sensing ion channel | |
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Chloride |
CaCCsTooltip Calcium-activated chloride channel | |
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CFTRTooltip Cystic fibrosis transmembrane conductance regulator | |
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Unsorted | |
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Others |
TRPsTooltip Transient receptor potential channels | |
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LGICsTooltip Ligand gated ion channels | |
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α1 | Agonists | |
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Antagonists |
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Abanoquil
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Ajmalicine
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Alfuzosin
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Anisodamine
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Anisodine
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Atiprosin
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Atypical antipsychotics (e.g.,
brexpiprazole,
clozapine,
olanzapine,
quetiapine,
risperidone)
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Benoxathian
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Beta blockers (e.g.,
adimolol,
amosulalol,
arotinolol,
carvedilol,
eugenodilol,
labetalol)
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Buflomedil
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Bunazosin
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Corynanthine
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Dapiprazole
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Domesticine
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Doxazosin
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Ergolines (e.g.,
acetergamine,
ergotamine,
dihydroergotamine,
lisuride,
nicergoline,
terguride)
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Etoperidone
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Fenspiride
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Hydroxyzine
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Indoramin
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Ketanserin
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L-765,314
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mCPP
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Mepiprazole
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Metazosin
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Monatepil
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Moxisylyte
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Naftopidil
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Nantenine
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Neldazosin
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Niaprazine
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Niguldipine
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Pardoprunox
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Pelanserin
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Perlapine
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Phendioxan
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Phenoxybenzamine
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Phentolamine
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Phenylpiperazine
antidepressants (e.g.,
hydroxynefazodone,
nefazodone,
trazodone,
triazoledione)
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Piperoxan
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Prazosin
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Quinazosin
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Quinidine
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Silodosin
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Spegatrine
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Spiperone
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Talipexole
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Tamsulosin
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Terazosin
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Tiodazosin
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Tolazoline
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Tetracyclic antidepressants (e.g.,
amoxapine,
maprotiline,
mianserin)
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Tricyclic antidepressants (e.g.,
amitriptyline,
clomipramine,
doxepin,
imipramine,
trimipramine)
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Trimazosin
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Typical antipsychotics (e.g.,
chlorpromazine,
fluphenazine,
loxapine,
thioridazine)
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Urapidil
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WB-4101
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Zolertine
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α2 | Agonists | |
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Antagonists |
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1-PP
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Adimolol
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Amesergide
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Aptazapine
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Atipamezole
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Atypical antipsychotics (e.g.,
asenapine,
brexpiprazole,
clozapine,
lurasidone,
olanzapine,
paliperidone,
quetiapine,
risperidone,
zotepine)
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Azapirones (e.g.,
buspirone,
gepirone,
ipsapirone,
tandospirone)
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BRL-44408
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Buflomedil
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Cirazoline
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Efaroxan
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Esmirtazapine
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Fenmetozole
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Fluparoxan
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Idazoxan
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Ketanserin
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Lisuride
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mCPP
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Mianserin
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Mirtazapine
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NAN-190
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Pardoprunox
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Phentolamine
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Phenoxybenzamine
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Piperoxan
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Piribedil
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Rauwolscine
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Rotigotine
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Setiptiline
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Spegatrine
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Spiroxatrine
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Sunepitron
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Terguride
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Tolazoline
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Typical antipsychotics (e.g.,
chlorpromazine,
fluphenazine,
loxapine,
thioridazine)
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Yohimbine
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β | |
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