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AHFS/ Drugs.com | International Drug Names |
Routes of administration | Oral |
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Chemical and physical data | |
Formula | C15H17NS2 |
Molar mass | 275.43 g·mol−1 |
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Tipepidine ( INN) (brand names Asverin, Antupex, Asvelik, Asvex, Bitiodin, Cofdenin A, Hustel, Nodal, Sotal), also known as tipepidine hibenzate ( JAN), is a synthetic, non- opioid antitussive and expectorant of the thiambutene class. [1] [2] It acts as an inhibitor of G protein-coupled inwardly-rectifying potassium channels (GIRKs). [3] The drug was discovered in the 1950s, [4] and was developed in Japan in 1959. [5] It is used as the hibenzate and citrate salts. [1] [5]
The usual dose is 20 mg every 4–6 hours.[ citation needed] Possible side effects of tipepidine, especially in overdose, may include drowsiness, vertigo, delirium, disorientation, loss of consciousness, and confusion. [5]
Tipepidine has been investigated as a potential psychiatric drug. It is being investigated in depression, [3] [6] [7] obsessive-compulsive disorder, [8] and attention-deficit hyperactivity disorder (ADHD). [9] [10] [11] Through inhibition of GIRK channels, tipepidine increases dopamine levels in the nucleus accumbens, but without increasing locomotor activity or producing methamphetamine-like behavioral sensitization, and this action appears to be at least partly responsible for its antidepressant-like effects in rodents. [12] [13]
Clinical data | |
---|---|
AHFS/ Drugs.com | International Drug Names |
Routes of administration | Oral |
ATC code | |
Legal status | |
Legal status |
|
Identifiers | |
| |
CAS Number | |
PubChem CID | |
ChemSpider | |
UNII | |
KEGG | |
CompTox Dashboard ( EPA) | |
Chemical and physical data | |
Formula | C15H17NS2 |
Molar mass | 275.43 g·mol−1 |
3D model ( JSmol) | |
| |
| |
(verify) |
Tipepidine ( INN) (brand names Asverin, Antupex, Asvelik, Asvex, Bitiodin, Cofdenin A, Hustel, Nodal, Sotal), also known as tipepidine hibenzate ( JAN), is a synthetic, non- opioid antitussive and expectorant of the thiambutene class. [1] [2] It acts as an inhibitor of G protein-coupled inwardly-rectifying potassium channels (GIRKs). [3] The drug was discovered in the 1950s, [4] and was developed in Japan in 1959. [5] It is used as the hibenzate and citrate salts. [1] [5]
The usual dose is 20 mg every 4–6 hours.[ citation needed] Possible side effects of tipepidine, especially in overdose, may include drowsiness, vertigo, delirium, disorientation, loss of consciousness, and confusion. [5]
Tipepidine has been investigated as a potential psychiatric drug. It is being investigated in depression, [3] [6] [7] obsessive-compulsive disorder, [8] and attention-deficit hyperactivity disorder (ADHD). [9] [10] [11] Through inhibition of GIRK channels, tipepidine increases dopamine levels in the nucleus accumbens, but without increasing locomotor activity or producing methamphetamine-like behavioral sensitization, and this action appears to be at least partly responsible for its antidepressant-like effects in rodents. [12] [13]