Clinical data | |
---|---|
Trade names | Atuss, Cothera, Cotrane, Perlatos, Pulmoll, Tussizid |
AHFS/ Drugs.com | International Drug Names |
ATC code | |
Identifiers | |
| |
CAS Number | |
PubChem CID | |
ChemSpider | |
UNII | |
KEGG | |
CompTox Dashboard ( EPA) | |
ECHA InfoCard | 100.006.838 |
Chemical and physical data | |
Formula | C19H22N2O3S |
Molar mass | 358.46 g·mol−1 |
3D model ( JSmol) | |
| |
| |
(verify) |
Dimethoxanate (trade names Cothera, Cotrane, Atuss, Perlatoss, Tossizid) [1] is a cough suppressant of the phenothiazine class. [2]
Dimethoxanate may have analgesic, local anesthetic, and central nervous system depressant effects, but it may also produce nausea and vomiting. [3]
It binds to the sigma-1 receptor in the brain with an IC50 of 41 nM. [4]
Dimethoxanate was introduced in Austria, Belgium, and France in 1911, and in Italy and Spain in 1963. [5] Approval for marketing in the US was withdrawn by the FDA in 1975 due to lack of evidence of efficacy. [6]
Phenothiazine (1) is reacted with phosgene to give Phenothiazine-10-carbonyl chloride [18956-87-1] (2). Further reaction with 2-(2-(dimethylamino)ethoxy)ethanol [1704-62-7] (3) completed the synthesis of Dimethoxanate (4).
Clinical data | |
---|---|
Trade names | Atuss, Cothera, Cotrane, Perlatos, Pulmoll, Tussizid |
AHFS/ Drugs.com | International Drug Names |
ATC code | |
Identifiers | |
| |
CAS Number | |
PubChem CID | |
ChemSpider | |
UNII | |
KEGG | |
CompTox Dashboard ( EPA) | |
ECHA InfoCard | 100.006.838 |
Chemical and physical data | |
Formula | C19H22N2O3S |
Molar mass | 358.46 g·mol−1 |
3D model ( JSmol) | |
| |
| |
(verify) |
Dimethoxanate (trade names Cothera, Cotrane, Atuss, Perlatoss, Tossizid) [1] is a cough suppressant of the phenothiazine class. [2]
Dimethoxanate may have analgesic, local anesthetic, and central nervous system depressant effects, but it may also produce nausea and vomiting. [3]
It binds to the sigma-1 receptor in the brain with an IC50 of 41 nM. [4]
Dimethoxanate was introduced in Austria, Belgium, and France in 1911, and in Italy and Spain in 1963. [5] Approval for marketing in the US was withdrawn by the FDA in 1975 due to lack of evidence of efficacy. [6]
Phenothiazine (1) is reacted with phosgene to give Phenothiazine-10-carbonyl chloride [18956-87-1] (2). Further reaction with 2-(2-(dimethylamino)ethoxy)ethanol [1704-62-7] (3) completed the synthesis of Dimethoxanate (4).