NAFTOPIDIL

Naftopidil
Clinical data
Trade names	Flivas
AHFS/ Drugs.com	International Drug Names
Routes of; administration	Oral
ATC code	none;
Legal status
Legal status	In general: ℞ (Prescription only);
Identifiers
	IUPAC name 1-[4-(2-methoxyphenyl)piperazin-1-yl]-3-(1-naphthyloxy)propan-2-ol;
CAS Number	57149-07-2 ;
PubChem CID	4418;
ChemSpider	4265 ;
UNII	R9PHW59SFN;
CompTox Dashboard ( EPA)	DTXSID5045176 ;
ECHA InfoCard	100.220.557
Chemical and physical data
Formula	C24H28N2O3
Molar mass	392.499 g·mol−1
3D model ( JSmol)	Interactive image;
	SMILES COC1=CC=CC=C1N2CCN(CC2)CC(COC3=CC=CC4=CC=CC=C43)O;
	InChI InChI=1S/C24H28N2O3/c1-28-24-11-5-4-10-22(24)26-15-13-25(14-16-26)17-20(27)18-29-23-12-6-8-19-7-2-3-9-21(19)23/h2-12,20,27H,13-18H2,1H3 ; Key:HRRBJVNMSRJFHQ-UHFFFAOYSA-N ;
	(verify)

Naftopidil ( INN, marketed under the brand name Flivas) is a drug used in benign prostatic hypertrophy which acts as a selective α₁-adrenergic receptor antagonist or alpha-1 blocker.^[1]

References

^ Sakai H, Igawa T, Onita T, Furukawa M, Hakariya T, Hayashi M, Matsuya F, Shida Y, Nishimura N, Yogi Y, Tsurusaki T, Takehara K, Nomata K, Shiraishi K, Shono T, Aoki D, Kanetake H (2011). "Efficacy of naftopidil in patients with overactive bladder associated with benign prostatic hyperplasia: prospective randomized controlled study to compare differences in efficacy between morning and evening medication". Hinyokika Kiyo. 57 (1): 7–13. PMID 21304253.

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Clinical data

Trade names	Flivas
AHFS/ Drugs.com	International Drug Names
Routes of administration	Oral
ATC code	none
Legal status
Legal status	In general: ℞ (Prescription only)
Identifiers
IUPAC name 1-[4-(2-methoxyphenyl)piperazin-1-yl]-3-(1-naphthyloxy)propan-2-ol
CAS Number	57149-07-2^Y
PubChem CID	4418
ChemSpider	4265^N
UNII	R9PHW59SFN
CompTox Dashboard ( EPA)	DTXSID5045176
ECHA InfoCard	100.220.557
Chemical and physical data
Formula	C₂₄H₂₈N₂O₃
Molar mass	392.499 g·mol⁻¹
3D model ( JSmol)	Interactive image
SMILES COC1=CC=CC=C1N2CCN(CC2)CC(COC3=CC=CC4=CC=CC=C43)O
InChI InChI=1S/C24H28N2O3/c1-28-24-11-5-4-10-22(24)26-15-13-25(14-16-26)17-20(27)18-29-23-12-6-8-19-7-2-3-9-21(19)23/h2-12,20,27H,13-18H2,1H3^N Key:HRRBJVNMSRJFHQ-UHFFFAOYSA-N^N
(verify)