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Phendioxan
Names
Preferred IUPAC name
2-(2,6-Dimethoxyphenoxy)-N -{[(2R ,3R )-3-phenyl-2,3-dihydro-1,4-benzodioxin-2-yl]methyl}ethan-1-amine
Identifiers
ChEMBL
ChemSpider
UNII
InChI=1S/C25H27NO5/c1-27-21-13-8-14-22(28-2)25(21)29-16-15-26-17-23-24(18-9-4-3-5-10-18)31-20-12-7-6-11-19(20)30-23/h3-14,23-24,26H,15-17H2,1-2H3/t23-,24-/m1/s1
Key: UVEKKXRFQCNLQE-DNQXCXABSA-N
InChI=1/C25H27NO5/c1-27-21-13-8-14-22(28-2)25(21)29-16-15-26-17-23-24(18-9-4-3-5-10-18)31-20-12-7-6-11-19(20)30-23/h3-14,23-24,26H,15-17H2,1-2H3/t23-,24-/m1/s1
Key: UVEKKXRFQCNLQE-DNQXCXABBD
COC1=C(C(=CC=C1)OC)OCCNC[C@@H]2[C@H](OC3=CC=CC=C3O2)C4=CC=CC=C4
Properties
C 25 H 27 N O 5
Molar mass
421.493 g·mol−1
Except where otherwise noted, data are given for materials in their
standard state (at 25 °C [77 °F], 100 kPa).
Chemical compound
Phendioxan is an
α1 -adrenergic receptor
antagonist .
[1]
See also
References
^ Quaglia, W; Pigini, M; Tayebati, SK; Piergentili, A; Giannella, M; Marucci, G; Melchiorre, C (1993). "Structure-activity relationships in 1,4-benzodioxan-related compounds. 4. Effect of aryl and alkyl substituents at position 3 on alpha-adrenoreceptor blocking activity". Journal of Medicinal Chemistry . 36 (11): 1520–8.
doi :
10.1021/jm00063a002 .
PMID
8098772 .
α1
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Alfuzosin
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Etoperidone
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Hydroxyzine
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L-765,314
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Naftopidil
Nantenine
Neldazosin
Niaprazine
Niguldipine
Pardoprunox
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Perlapine
Phendioxan
Phenoxybenzamine
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WB-4101
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asenapine ,
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clozapine ,
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Typical antipsychotics (e.g.,
chlorpromazine ,
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loxapine ,
thioridazine )
Yohimbine
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