From Wikipedia, the free encyclopedia
Quinazosin
Names
Preferred IUPAC name
6,7-Dimethoxy-2-[4-(prop-2-en-1-yl)piperazin-1-yl]quinazolin-4-amine
Identifiers
ChemSpider
UNII
InChI=1S/C17H23N5O2/c1-4-5-21-6-8-22(9-7-21)17-19-13-11-15(24-3)14(23-2)10-12(13)16(18)20-17/h4,10-11H,1,5-9H2,2-3H3,(H2,18,19,20)
Key: HSIPLPKNLDWHSE-UHFFFAOYSA-N
InChI=1/C17H23N5O2/c1-4-5-21-6-8-22(9-7-21)17-19-13-11-15(24-3)14(23-2)10-12(13)16(18)20-17/h4,10-11H,1,5-9H2,2-3H3,(H2,18,19,20)
Key: HSIPLPKNLDWHSE-UHFFFAOYAT
COC1=C(C=C2C(=C1)C(=NC(=N2)N3CCN(CC3)CC=C)N)OC
Properties
C 17 H 23 N 5 O 2
Molar mass
329.404 g·mol−1
Except where otherwise noted, data are given for materials in their
standard state (at 25 °C [77 °F], 100 kPa).
Chemical compound
Quinazosin is an
antihypertensive
α1 -adrenergic receptor
antagonist .
[1]
References
^ Martin, RA; Barsoum, NJ; Sturgess, JM; De La Iglesia, FA (1985). "Leukocyte and bone marrow effects of a thiomorpholine quinazosin antihypertensive agent". Toxicology and Applied Pharmacology . 81 (1): 166–73.
doi :
10.1016/0041-008x(85)90131-0 .
PMID
3840293 .
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β