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Chemical compound
Atiprosin
Other names AY-28,228
Routes of administration
Oral
ATC code
(4aR ,12bS )-1-ethyl-12-methyl-4-(propan-2-yl)-1,2,3,4,4a,5,6,12b-octahydropyrazino[2',3':3,4]pyrido[1,2-a]indole
CAS Number
PubChem
CID
ChemSpider
UNII
ChEMBL
Formula C 20 H 29 N 3
Molar mass 311.473 g·mol−1 3D model (
JSmol )
n23c1ccccc1c(c2[C@H]4N(CCN([C@@H]4CC3)C(C)C)CC)C
InChI=1S/C20H29N3/c1-5-21-12-13-22(14(2)3)18-10-11-23-17-9-7-6-8-16(17)15(4)19(23)20(18)21/h6-9,14,18,20H,5,10-13H2,1-4H3/t18-,20+/m1/s1
Y Key:WXNVFYIBELASJW-QUCCMNQESA-N
Y
N Y
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(verify)
Atiprosin (developmental code name AY-28,228 ) is an
antihypertensive
agent which acts as a
selective
α1 -adrenergic receptor
antagonist .
[1]
[2]
[3]
[4] It also possesses some
antihistamine activity, though it is some 15-fold weaker in this regard than as an
alpha blocker .
[3] It was never marketed.
[1]
See also
References
^
a
b David J. Triggle (1996).
Dictionary of Pharmacological Agents . Boca Raton: Chapman & Hall/CRC.
ISBN
0-412-46630-9 .
^ Jirkovsky I, Santroch G, Baudy R, Oshiro G (February 1987). "Octahydropyrazino[2',3':3,4]pyrido[1,2-a]indoles. A new class of potent antihypertensive agents". Journal of Medicinal Chemistry . 30 (2): 388–94.
doi :
10.1021/jm00385a022 .
PMID
3806618 .
^
a
b Grimes D, Rimele TJ, Henry DE, et al. (September 1987).
"In vitro isolated tissue studies with atiprosin (AY-28,228): a new antihypertensive compound" . Journal of Cardiovascular Pharmacology . 10 (3): 249–58.
doi :
10.1097/00005344-198709000-00001 .
PMID
2444771 .
S2CID
9361176 .
^ Oshiro G, Wojdan A, Klein M, Metcalf G (September 1987).
"Antihypertensive and hypotensive actions of atiprosin (AY-28,228) in rats, dogs, and monkeys" . Journal of Cardiovascular Pharmacology . 10 (3): 341–9.
doi :
10.1097/00005344-198709000-00014 .
PMID
2444784 .
S2CID
19086175 .
External links
Media related to
Atiprosin at Wikimedia Commons
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clozapine ,
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Benoxathian
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L-765,314
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Nantenine
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Perlapine
Phendioxan
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Quinidine
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Talipexole
Tamsulosin
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Tiodazosin
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mianserin )
Tricyclic antidepressants (e.g.,
amitriptyline ,
clomipramine ,
doxepin ,
imipramine ,
trimipramine )
Trimazosin
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chlorpromazine ,
fluphenazine ,
loxapine ,
thioridazine )
Urapidil
WB-4101
Zolertine
α2
Agonists Antagonists
1-PP
Adimolol
Amesergide
Aptazapine
Atipamezole
Atypical antipsychotics (e.g.,
asenapine ,
brexpiprazole ,
clozapine ,
lurasidone ,
olanzapine ,
paliperidone ,
quetiapine ,
risperidone ,
zotepine )
Azapirones (e.g.,
buspirone ,
gepirone ,
ipsapirone ,
tandospirone )
BRL-44408
Buflomedil
Cirazoline
Efaroxan
Esmirtazapine
Fenmetozole
Fluparoxan
Idazoxan
Ketanserin
Lisuride
mCPP
Mianserin
Mirtazapine
NAN-190
Pardoprunox
Phentolamine
Phenoxybenzamine
Piperoxan
Piribedil
Rauwolscine
Rotigotine
Setiptiline
Spegatrine
Spiroxatrine
Sunepitron
Terguride
Tolazoline
Typical antipsychotics (e.g.,
chlorpromazine ,
fluphenazine ,
loxapine ,
thioridazine )
Yohimbine
β
H1
Agonists Antagonists
Others:
Atypical antipsychotics (e.g.,
aripiprazole ,
asenapine ,
brexpiprazole ,
brilaroxazine ,
clozapine ,
iloperidone ,
olanzapine ,
paliperidone ,
quetiapine ,
risperidone ,
ziprasidone ,
zotepine )
Phenylpiperazine
antidepressants (e.g.,
hydroxynefazodone ,
nefazodone ,
trazodone ,
triazoledione )
Tetracyclic antidepressants (e.g.,
amoxapine ,
loxapine ,
maprotiline ,
mianserin ,
mirtazapine ,
oxaprotiline )
Tricyclic antidepressants (e.g.,
amitriptyline ,
butriptyline ,
clomipramine ,
desipramine ,
dosulepin (dothiepin) ,
doxepin ,
imipramine ,
iprindole ,
lofepramine ,
nortriptyline ,
protriptyline ,
trimipramine )
Typical antipsychotics (e.g.,
chlorpromazine ,
flupenthixol ,
fluphenazine ,
loxapine ,
perphenazine ,
prochlorperazine ,
thioridazine ,
thiothixene )
H2
H3
H4