Clinical data | |
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Pronunciation | /ˌhɛksoʊˈprɛnəliːn/ HEKS-oh-PREN-ə-leen |
Other names | 4-[2-[6-[[2-(3,4-dihydroxyphenyl)-2-hydroxyethyl]amino]hexylamino]-1-hydroxyethyl]benzene-1,2-diol |
AHFS/ Drugs.com | International Drug Names |
Routes of administration | Oral ( tablets), IV |
ATC code | |
Legal status | |
Legal status |
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Pharmacokinetic data | |
Bioavailability | 5–11% ( Tmax = 2 hours) |
Metabolism | COMT (slow O-methylation) |
Elimination half-life | ~50 minutes (if taken orally) |
Excretion | Feces (~90%) [1] |
Identifiers | |
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CAS Number | |
PubChem CID | |
DrugBank | |
ChemSpider | |
UNII | |
KEGG | |
CompTox Dashboard ( EPA) | |
Chemical and physical data | |
Formula | C22H32N2O6 |
Molar mass | 420.506 g·mol−1 |
3D model ( JSmol) | |
Chirality | Racemic mixture |
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(what is this?) (verify) |
Hexoprenaline is a selective β2 adrenergic receptor agonist used in the treatment of asthma. [2] Hexoprenaline is also used in some countries (such as Russia and Switzerland) as a tocolytic agent (i.e., labor suppressant), with the most common trade name being Gynipral. [3] [4] It is not approved by the United States Food and Drug Administration.
When used as a tocolytic, hexoprenaline is contraindicated in:
It should be used with caution in people with gestational diabetes.
When concomitantly administered:
Hexoprenaline is contraindicated for use with monoamine oxidase inhibitors (MAOIs), tricyclic antidepressant (TCAs), ergot alkaloids, and dihydrotachysterol. [3]
Clinical data | |
---|---|
Pronunciation | /ˌhɛksoʊˈprɛnəliːn/ HEKS-oh-PREN-ə-leen |
Other names | 4-[2-[6-[[2-(3,4-dihydroxyphenyl)-2-hydroxyethyl]amino]hexylamino]-1-hydroxyethyl]benzene-1,2-diol |
AHFS/ Drugs.com | International Drug Names |
Routes of administration | Oral ( tablets), IV |
ATC code | |
Legal status | |
Legal status |
|
Pharmacokinetic data | |
Bioavailability | 5–11% ( Tmax = 2 hours) |
Metabolism | COMT (slow O-methylation) |
Elimination half-life | ~50 minutes (if taken orally) |
Excretion | Feces (~90%) [1] |
Identifiers | |
| |
CAS Number | |
PubChem CID | |
DrugBank | |
ChemSpider | |
UNII | |
KEGG | |
CompTox Dashboard ( EPA) | |
Chemical and physical data | |
Formula | C22H32N2O6 |
Molar mass | 420.506 g·mol−1 |
3D model ( JSmol) | |
Chirality | Racemic mixture |
| |
| |
(what is this?) (verify) |
Hexoprenaline is a selective β2 adrenergic receptor agonist used in the treatment of asthma. [2] Hexoprenaline is also used in some countries (such as Russia and Switzerland) as a tocolytic agent (i.e., labor suppressant), with the most common trade name being Gynipral. [3] [4] It is not approved by the United States Food and Drug Administration.
When used as a tocolytic, hexoprenaline is contraindicated in:
It should be used with caution in people with gestational diabetes.
When concomitantly administered:
Hexoprenaline is contraindicated for use with monoamine oxidase inhibitors (MAOIs), tricyclic antidepressant (TCAs), ergot alkaloids, and dihydrotachysterol. [3]