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Tampramine
Clinical data
Routes of
administration		Oral
Legal status
Legal status
  • In general: uncontrolled
Identifiers
  • N,N-Dimethyl-3-(6-phenylpyrido[2,3-b][1,4]benzodiazepin-11-yl)propan-1-amine
CAS Number
PubChem CID
ChemSpider
UNII
CompTox Dashboard ( EPA)
Chemical and physical data
FormulaC23H24N4
Molar mass356.473 g·mol−1
3D model ( JSmol)
  • CN(C)CCCN1c2ccccc2C(=Nc3c1nccc3)c4ccccc4

Tampramine (AHR-9,377) is a tricyclic antidepressant (TCA) which was developed in the 1980s but was never marketed. [1] [2] Despite being a TCA, it acts as a selective norepinephrine reuptake inhibitor and has negligible affinity for adrenergic, histaminergic, and muscarinic receptors. [1] It was found to be effective in the forced swim test (FST) model of depression in animal studies but is not known to have ever been trialed in humans. [2]

See also

References

  1. ^ a b Kinnier WJ, Tabor RD, Norrell LY (October 1984). "Neurochemical properties of AHR-9377: a novel inhibitor of norepinephrine reuptake". Biochemical Pharmacology. 33 (19): 3001–5. doi: 10.1016/0006-2952(84)90600-2. PMID  6548381.
  2. ^ a b O'Donnell JM, Seiden LS (1985). "Effect of the experimental antidepressant AHR-9377 on performance during differential reinforcement of low response rate". Psychopharmacology. 87 (3): 283–5. doi: 10.1007/BF00432708. PMID  3936083. S2CID  20677730.
Retrieved from " https://en.wikipedia.org/?title=Tampramine&oldid=1082623448"
From Wikipedia, the free encyclopedia
Tampramine
Clinical data
Routes of
administration		Oral
Legal status
Legal status
  • In general: uncontrolled
Identifiers
  • N,N-Dimethyl-3-(6-phenylpyrido[2,3-b][1,4]benzodiazepin-11-yl)propan-1-amine
CAS Number
PubChem CID
ChemSpider
UNII
CompTox Dashboard ( EPA)
Chemical and physical data
FormulaC23H24N4
Molar mass356.473 g·mol−1
3D model ( JSmol)
  • CN(C)CCCN1c2ccccc2C(=Nc3c1nccc3)c4ccccc4

Tampramine (AHR-9,377) is a tricyclic antidepressant (TCA) which was developed in the 1980s but was never marketed. [1] [2] Despite being a TCA, it acts as a selective norepinephrine reuptake inhibitor and has negligible affinity for adrenergic, histaminergic, and muscarinic receptors. [1] It was found to be effective in the forced swim test (FST) model of depression in animal studies but is not known to have ever been trialed in humans. [2]

See also

References

  1. ^ a b Kinnier WJ, Tabor RD, Norrell LY (October 1984). "Neurochemical properties of AHR-9377: a novel inhibitor of norepinephrine reuptake". Biochemical Pharmacology. 33 (19): 3001–5. doi: 10.1016/0006-2952(84)90600-2. PMID  6548381.
  2. ^ a b O'Donnell JM, Seiden LS (1985). "Effect of the experimental antidepressant AHR-9377 on performance during differential reinforcement of low response rate". Psychopharmacology. 87 (3): 283–5. doi: 10.1007/BF00432708. PMID  3936083. S2CID  20677730.
Retrieved from " https://en.wikipedia.org/?title=Tampramine&oldid=1082623448"

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