Names | |
---|---|
Preferred IUPAC name
Sodium 2-hydroxybenzoate | |
Other names
Salsonin, Monosodium salicylate, Sodium o-hydroxybenzoate, Salicylic acid sodium salt, Monosodium 2-hydroxybenzoate, Diuratin
| |
Identifiers | |
3D model (
JSmol)
|
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ChEMBL | |
ChemSpider | |
DrugBank | |
ECHA InfoCard | 100.000.181 |
EC Number |
|
KEGG | |
PubChem
CID
|
|
RTECS number |
|
UNII | |
CompTox Dashboard (
EPA)
|
|
| |
| |
Properties | |
C7H5NaO3 | |
Molar mass | 160.104 g/mol |
Appearance | White crystals |
Melting point | 200 °C (392 °F; 473 K) |
25.08 g/100 g (-1.5 °C) 107.9 g/100 g (15 °C) 124.6 g/100 g (25 °C) 141.8 g/100 g (78.5 °C) 179 g/100 g (114 °C) [1] | |
Solubility | Soluble in glycerol, 1,4-Dioxane, alcohol [1] |
Solubility in methanol | 26.28 g/100 g (15 °C) 34.73 g/100 g (67.2 °C) [1] |
Pharmacology | |
N02BA04 ( WHO) | |
Hazards | |
Occupational safety and health (OHS/OSH): | |
Main hazards
|
Harmful |
Eye hazards
|
Irritant |
GHS labelling: [3] | |
Warning | |
H314, H331, H400 | |
P210, P261, P273, P280, P305+P351+P338, P310 | |
NFPA 704 (fire diamond) | |
250 °C (482 °F; 523 K) | |
Lethal dose or concentration (LD, LC): | |
LD50 (
median dose)
|
930 mg/kg (rats, oral) [2] |
Except where otherwise noted, data are given for materials in their
standard state (at 25 °C [77 °F], 100 kPa).
|
Sodium salicylate is a sodium salt of salicylic acid. It can be prepared from sodium phenolate and carbon dioxide under higher temperature and pressure. Historically, it has been synthesized by refluxing methyl salicylate ( wintergreen oil) with an excess of sodium hydroxide. [4]
Sodium salicylate is of the salicylate family.
It is used in medicine as an analgesic and antipyretic. Sodium salicylate also acts as non-steroidal anti-inflammatory drug (NSAID), and induces apoptosis in cancer cells [5] [6] [7] and also necrosis. [8] It is also a potential replacement for aspirin for people sensitive to it. It may also be used as a phosphor for the detection of vacuum ultraviolet radiation and electrons. [9]
Names | |
---|---|
Preferred IUPAC name
Sodium 2-hydroxybenzoate | |
Other names
Salsonin, Monosodium salicylate, Sodium o-hydroxybenzoate, Salicylic acid sodium salt, Monosodium 2-hydroxybenzoate, Diuratin
| |
Identifiers | |
3D model (
JSmol)
|
|
ChEMBL | |
ChemSpider | |
DrugBank | |
ECHA InfoCard | 100.000.181 |
EC Number |
|
KEGG | |
PubChem
CID
|
|
RTECS number |
|
UNII | |
CompTox Dashboard (
EPA)
|
|
| |
| |
Properties | |
C7H5NaO3 | |
Molar mass | 160.104 g/mol |
Appearance | White crystals |
Melting point | 200 °C (392 °F; 473 K) |
25.08 g/100 g (-1.5 °C) 107.9 g/100 g (15 °C) 124.6 g/100 g (25 °C) 141.8 g/100 g (78.5 °C) 179 g/100 g (114 °C) [1] | |
Solubility | Soluble in glycerol, 1,4-Dioxane, alcohol [1] |
Solubility in methanol | 26.28 g/100 g (15 °C) 34.73 g/100 g (67.2 °C) [1] |
Pharmacology | |
N02BA04 ( WHO) | |
Hazards | |
Occupational safety and health (OHS/OSH): | |
Main hazards
|
Harmful |
Eye hazards
|
Irritant |
GHS labelling: [3] | |
Warning | |
H314, H331, H400 | |
P210, P261, P273, P280, P305+P351+P338, P310 | |
NFPA 704 (fire diamond) | |
250 °C (482 °F; 523 K) | |
Lethal dose or concentration (LD, LC): | |
LD50 (
median dose)
|
930 mg/kg (rats, oral) [2] |
Except where otherwise noted, data are given for materials in their
standard state (at 25 °C [77 °F], 100 kPa).
|
Sodium salicylate is a sodium salt of salicylic acid. It can be prepared from sodium phenolate and carbon dioxide under higher temperature and pressure. Historically, it has been synthesized by refluxing methyl salicylate ( wintergreen oil) with an excess of sodium hydroxide. [4]
Sodium salicylate is of the salicylate family.
It is used in medicine as an analgesic and antipyretic. Sodium salicylate also acts as non-steroidal anti-inflammatory drug (NSAID), and induces apoptosis in cancer cells [5] [6] [7] and also necrosis. [8] It is also a potential replacement for aspirin for people sensitive to it. It may also be used as a phosphor for the detection of vacuum ultraviolet radiation and electrons. [9]