Clinical data | |
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AHFS/ Drugs.com | International Drug Names |
ATC code | |
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CAS Number | |
PubChem CID | |
ChemSpider | |
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KEGG | |
Chemical and physical data | |
Formula | C23H28O6 |
Molar mass | 400.471 g·mol−1 |
3D model ( JSmol) | |
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(verify) |
Enprostil is a synthetic prostaglandin designed to resemble dinoprostone. Enprostil was found to be a highly potent inhibitor of gastric HCl secretion. [1] It is an analog of prostaglandin E2 but unlike this prostaglandin, which binds to and activates all four cellular receptors viz., EP1, EP2, EP3, and EP4 receptors, enprostil is a more selective receptor agonist in that it binds to and activates primarily the EP3 receptor. [2] Consequently, enprostil is expected to have a narrower range of actions that may avoid some of the unwanted side-effects and toxicities of prostaglandin E2. A prospective multicenter randomized controlled trial conducted in Japan found combining enprostil with cimetidine was more effective than cimetidine alone in treating gastric ulcer. [3]
{{
cite journal}}
: CS1 maint: DOI inactive as of April 2024 (
link)Clinical data | |
---|---|
AHFS/ Drugs.com | International Drug Names |
ATC code | |
Identifiers | |
| |
CAS Number | |
PubChem CID | |
ChemSpider | |
UNII | |
KEGG | |
Chemical and physical data | |
Formula | C23H28O6 |
Molar mass | 400.471 g·mol−1 |
3D model ( JSmol) | |
| |
| |
(verify) |
Enprostil is a synthetic prostaglandin designed to resemble dinoprostone. Enprostil was found to be a highly potent inhibitor of gastric HCl secretion. [1] It is an analog of prostaglandin E2 but unlike this prostaglandin, which binds to and activates all four cellular receptors viz., EP1, EP2, EP3, and EP4 receptors, enprostil is a more selective receptor agonist in that it binds to and activates primarily the EP3 receptor. [2] Consequently, enprostil is expected to have a narrower range of actions that may avoid some of the unwanted side-effects and toxicities of prostaglandin E2. A prospective multicenter randomized controlled trial conducted in Japan found combining enprostil with cimetidine was more effective than cimetidine alone in treating gastric ulcer. [3]
{{
cite journal}}
: CS1 maint: DOI inactive as of April 2024 (
link)