Combination of | |
---|---|
Oxycodone | Opioid analgesic |
Paracetamol | Anilide analgesic |
Clinical data | |
Trade names | Percocet, others |
AHFS/ Drugs.com | Professional Drug Facts |
License data | |
Routes of administration | By mouth |
ATC code | |
Legal status | |
Legal status |
|
Identifiers | |
CAS Number | |
ChemSpider | |
KEGG | |
CompTox Dashboard ( EPA) | |
(what is this?) (verify) |
Oxycodone/paracetamol, sold under the brand name Percocet among others, is a fixed-dose combination of the opioid oxycodone with paracetamol (acetaminophen), used to treat moderate to severe pain. [1]
In 2021, it was the 75th most commonly prescribed medication in the United States, with more than 8 million prescriptions. [2] [3]
The United States Food and Drug Administration (FDA) first approved Percocet in 1976, under application ANDA 085106. [4]
In June 2009, an FDA advisory panel recommended that Percocet, Vicodin, and every other combination of acetaminophen with narcotic analgesics [5] be limited in their sales because of their contributions to an alleged 400 acetaminophen-related deaths in the U.S. each year, that were attributed to acetaminophen overdose and associated liver damage. [6]
In December 2009, the Canadian Medical Association Journal reported a study finding a fivefold increase in oxycodone-related deaths in Ontario (mostly accidental) between 1991 and 2007 that led to a doubling of all opioid-related deaths in Ontario over the same period. [7] [8] [9]
In March 2017, US President Donald Trump initiated the Opioid and Drug Abuse Commission. [10] In July 2017, a draft report was published. [11]
Combination of | |
---|---|
Oxycodone | Opioid analgesic |
Paracetamol | Anilide analgesic |
Clinical data | |
Trade names | Percocet, others |
AHFS/ Drugs.com | Professional Drug Facts |
License data | |
Routes of administration | By mouth |
ATC code | |
Legal status | |
Legal status |
|
Identifiers | |
CAS Number | |
ChemSpider | |
KEGG | |
CompTox Dashboard ( EPA) | |
(what is this?) (verify) |
Oxycodone/paracetamol, sold under the brand name Percocet among others, is a fixed-dose combination of the opioid oxycodone with paracetamol (acetaminophen), used to treat moderate to severe pain. [1]
In 2021, it was the 75th most commonly prescribed medication in the United States, with more than 8 million prescriptions. [2] [3]
The United States Food and Drug Administration (FDA) first approved Percocet in 1976, under application ANDA 085106. [4]
In June 2009, an FDA advisory panel recommended that Percocet, Vicodin, and every other combination of acetaminophen with narcotic analgesics [5] be limited in their sales because of their contributions to an alleged 400 acetaminophen-related deaths in the U.S. each year, that were attributed to acetaminophen overdose and associated liver damage. [6]
In December 2009, the Canadian Medical Association Journal reported a study finding a fivefold increase in oxycodone-related deaths in Ontario (mostly accidental) between 1991 and 2007 that led to a doubling of all opioid-related deaths in Ontario over the same period. [7] [8] [9]
In March 2017, US President Donald Trump initiated the Opioid and Drug Abuse Commission. [10] In July 2017, a draft report was published. [11]