Sinomenine or cocculine is an
alkaloid found in the root of the climbing plant Sinomenium acutum which is native to Japan and China. The plant is traditionally used in
herbal medicine in these countries for
rheumatism and
arthritis.[1] However, its analgesic action against other kinds of pain is limited. Sinomenine is a
morphinan derivative, related to
opioids such as
levorphanol and the non-opioid cough suppressant
dextromethorphan. Its anti-rheumatic effects are thought to be primarily mediated via release of
histamine,[2] but other effects such as inhibition of
prostaglandin,
leukotriene and
nitric oxide synthesis may also be involved.[3]
^Yamasaki H (February 1976). "Pharmacology of sinomenine, an anti-rheumatic alkaloid from Sinomenium acutum". Acta Medica Okayama. 30 (1): 1–20.
PMID61710.
^Liu L, Riese J, Resch K, Kaever V (November 1994). "Impairment of macrophage eicosanoid and nitric oxide production by an alkaloid from Sinomenium acutum". Arzneimittel-Forschung. 44 (11): 1223–6.
PMID7848335.
Sinomenine or cocculine is an
alkaloid found in the root of the climbing plant Sinomenium acutum which is native to Japan and China. The plant is traditionally used in
herbal medicine in these countries for
rheumatism and
arthritis.[1] However, its analgesic action against other kinds of pain is limited. Sinomenine is a
morphinan derivative, related to
opioids such as
levorphanol and the non-opioid cough suppressant
dextromethorphan. Its anti-rheumatic effects are thought to be primarily mediated via release of
histamine,[2] but other effects such as inhibition of
prostaglandin,
leukotriene and
nitric oxide synthesis may also be involved.[3]
^Yamasaki H (February 1976). "Pharmacology of sinomenine, an anti-rheumatic alkaloid from Sinomenium acutum". Acta Medica Okayama. 30 (1): 1–20.
PMID61710.
^Liu L, Riese J, Resch K, Kaever V (November 1994). "Impairment of macrophage eicosanoid and nitric oxide production by an alkaloid from Sinomenium acutum". Arzneimittel-Forschung. 44 (11): 1223–6.
PMID7848335.