BSPP is a compound used in scientific research which acts as a
positive allosteric modulator at the
GABABreceptor.[1] It has a synergistic effect with GABAB agonists such as
baclofen at GABAB autoreceptors but not heteroreceptors, suggesting it may be useful for distinguishing between these GABAB receptor subtypes.[2]
References
^Kerr DI, Khalafy J, Ong J, Perkins MV, Prager RH, Puspawati NM, Rimaz M (September 2006). "Synthesis and biological activity of allosteric modulators of GABAB receptors, part 2. 3-(2, 6-bis-tert-butyl-4-hydroxyphenyl) propanols". Australian Journal of Chemistry. 59 (7): 457–62.
doi:
10.1071/CH06164.
^Parker DA, Marino V, Ong J, Puspawati NM, Prager RH (September 2008). "The CGP7930 analogue 2,6-di-tert-butyl-4-(3-hydroxy-2-spiropentylpropyl)-phenol (BSPP) potentiates baclofen action at GABA(B) autoreceptors". Clinical and Experimental Pharmacology & Physiology. 35 (9): 1113–5.
doi:
10.1111/j.1440-1681.2008.04948.x.
PMID18430050.
S2CID25608408.
BSPP is a compound used in scientific research which acts as a
positive allosteric modulator at the
GABABreceptor.[1] It has a synergistic effect with GABAB agonists such as
baclofen at GABAB autoreceptors but not heteroreceptors, suggesting it may be useful for distinguishing between these GABAB receptor subtypes.[2]
References
^Kerr DI, Khalafy J, Ong J, Perkins MV, Prager RH, Puspawati NM, Rimaz M (September 2006). "Synthesis and biological activity of allosteric modulators of GABAB receptors, part 2. 3-(2, 6-bis-tert-butyl-4-hydroxyphenyl) propanols". Australian Journal of Chemistry. 59 (7): 457–62.
doi:
10.1071/CH06164.
^Parker DA, Marino V, Ong J, Puspawati NM, Prager RH (September 2008). "The CGP7930 analogue 2,6-di-tert-butyl-4-(3-hydroxy-2-spiropentylpropyl)-phenol (BSPP) potentiates baclofen action at GABA(B) autoreceptors". Clinical and Experimental Pharmacology & Physiology. 35 (9): 1113–5.
doi:
10.1111/j.1440-1681.2008.04948.x.
PMID18430050.
S2CID25608408.