1-(4-Chlorophenyl)silatrane is an extremely toxic[2]organosilicon compound which was developed by
M&T Chemicals as a single-dose
rodenticide.[1] It was never registered as rodenticide,[2] except for experimental use.[1] 1-(4-Chlorophenyl)silatrane was one of the chemicals studied in the
Project Coast.[3][4]
Toxicity
1-(4-Chlorophenyl)silatrane is a
GABA receptor antagonist[5] and it destroys nervous functions in the central nervous system of vertebrates, primarily in the brain and possibly in the brain stem.[6][7][8] It's a rapid acting
convulsant, causing convulsions within 1 minute in mice and rats. Death occurred within 5 minutes.[9] It is therefore likely to induce
poison shyness.[2] In field trials, it was less effective than
zinc phosphide against wild rats.[10]
^Casida, John E.; Eto, Morifusa; Moscioni, A.David; Engel, Judith L.; Milbrath, Dean S.; Verkade, John G. (1976). "Structure-toxicity relationships of 2,6,7-trioxabicyclo[2.2.2]-octanes and related compounds". Toxicology and Applied Pharmacology. 36 (2). Elsevier BV: 261–279.
doi:
10.1016/0041-008x(76)90006-5.
ISSN0041-008X.
PMID1084063.
^Mattson, H.; Brandt, K.; Heilbronn, E. (21–26 August 1977). Proceedings of the International Society of Neurochemistry. Sixth International Meeting of the International Society for Neurochemistry. Copenhagen, Denmark. p. 56.
^Voronkov, Michail G. (1979). "Biological activity of silatranes". Topics in Current Chemistry. Vol. 84. Berlin/Heidelberg: Springer-Verlag. pp. 77–135.
doi:
10.1007/bfb0048523.
ISBN3-540-09347-8.
PMID388722.
1-(4-Chlorophenyl)silatrane is an extremely toxic[2]organosilicon compound which was developed by
M&T Chemicals as a single-dose
rodenticide.[1] It was never registered as rodenticide,[2] except for experimental use.[1] 1-(4-Chlorophenyl)silatrane was one of the chemicals studied in the
Project Coast.[3][4]
Toxicity
1-(4-Chlorophenyl)silatrane is a
GABA receptor antagonist[5] and it destroys nervous functions in the central nervous system of vertebrates, primarily in the brain and possibly in the brain stem.[6][7][8] It's a rapid acting
convulsant, causing convulsions within 1 minute in mice and rats. Death occurred within 5 minutes.[9] It is therefore likely to induce
poison shyness.[2] In field trials, it was less effective than
zinc phosphide against wild rats.[10]
^Casida, John E.; Eto, Morifusa; Moscioni, A.David; Engel, Judith L.; Milbrath, Dean S.; Verkade, John G. (1976). "Structure-toxicity relationships of 2,6,7-trioxabicyclo[2.2.2]-octanes and related compounds". Toxicology and Applied Pharmacology. 36 (2). Elsevier BV: 261–279.
doi:
10.1016/0041-008x(76)90006-5.
ISSN0041-008X.
PMID1084063.
^Mattson, H.; Brandt, K.; Heilbronn, E. (21–26 August 1977). Proceedings of the International Society of Neurochemistry. Sixth International Meeting of the International Society for Neurochemistry. Copenhagen, Denmark. p. 56.
^Voronkov, Michail G. (1979). "Biological activity of silatranes". Topics in Current Chemistry. Vol. 84. Berlin/Heidelberg: Springer-Verlag. pp. 77–135.
doi:
10.1007/bfb0048523.
ISBN3-540-09347-8.
PMID388722.