From Wikipedia, the free encyclopedia
Chemical compound
Tolgabide
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4-{[(E)-(3-Chloro-5-methyl-6-oxocyclohexa-2,4-dien-1-ylidene)(4-chlorophenyl)methyl]amino}butanamide
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Formula | C18H18Cl2N2O2 |
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Molar mass | 365.25 g·mol−1 |
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3D model (
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Cc1cc(cc(c1O)/C(=N/CCCC(=O)N)/c2ccc(cc2)Cl)Cl
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InChI=1S/C18H18Cl2N2O2/c1-11-9-14(20)10-15(18(11)24)17(22-8-2-3-16(21)23)12-4-6-13(19)7-5-12/h4-7,9-10,24H,2-3,8H2,1H3,(H2,21,23)/b22-17+ Key:AOAFGVWKONLQRN-OQKWZONESA-N
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Tolgabide (
INN; development code SL-81.0142) is a
drug which was patented by
Synthélabo as an
anticonvulsant but was never marketed.
[1] It is an
analogue of
progabide and acts similarly to it as a
prodrug of
GABA, and therefore as an indirect
agonist of the
GABA receptors.
[1]
[2]
See also
References
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Ionotropic |
GABAATooltip γ-Aminobutyric acid A receptor |
- Positive modulators (abridged; see
here for a full list):
α-EMTBL
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Alcohols (e.g.,
drinking alcohol,
2M2B)
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Anabolic steroids
-
Avermectins (e.g.,
ivermectin)
-
Barbiturates (e.g.,
phenobarbital)
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Benzodiazepines (e.g.,
diazepam)
-
Bromide compounds (e.g.,
potassium bromide)
-
Carbamates (e.g.,
meprobamate)
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Carbamazepine
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Chloralose
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Chlormezanone
-
Clomethiazole
-
Dihydroergolines (e.g.,
ergoloid (dihydroergotoxine))
-
Etazepine
-
Etifoxine
-
Fenamates (e.g.,
mefenamic acid)
-
Flavonoids (e.g.,
apigenin,
hispidulin)
-
Fluoxetine
-
Flupirtine
-
Imidazoles (e.g.,
etomidate)
-
Kava constituents (e.g.,
kavain)
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Lanthanum
-
Loreclezole
-
Monastrol
-
Neuroactive steroids (e.g.,
allopregnanolone,
cholesterol,
THDOC)
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Niacin
-
Niacinamide
-
Nonbenzodiazepines (e.g.,
β-carbolines (e.g.,
abecarnil),
cyclopyrrolones (e.g.,
zopiclone),
imidazopyridines (e.g.,
zolpidem),
pyrazolopyrimidines (e.g.,
zaleplon))
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Norfluoxetine
-
Petrichloral
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Phenols (e.g.,
propofol)
-
Phenytoin
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Piperidinediones (e.g.,
glutethimide)
-
Propanidid
-
Pyrazolopyridines (e.g.,
etazolate)
-
Quinazolinones (e.g.,
methaqualone)
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Retigabine (ezogabine)
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ROD-188
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Skullcap constituents (e.g.,
baicalin)
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Stiripentol
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Sulfonylalkanes (e.g.,
sulfonmethane (sulfonal))
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Topiramate
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Valerian constituents (e.g.,
valerenic acid)
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Volatiles/
gases (e.g.,
chloral hydrate,
chloroform,
diethyl ether,
paraldehyde,
sevoflurane)
- Negative modulators:
1,3M1B
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3M2B
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11-Ketoprogesterone
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17-Phenylandrostenol
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α3IA
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α5IA (LS-193,268)
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β-CCB
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β-CCE
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β-CCM
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β-CCP
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β-EMGBL
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Anabolic steroids
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Amiloride
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Anisatin
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β-Lactams (e.g.,
penicillins,
cephalosporins,
carbapenems)
-
Basmisanil
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Bemegride
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Bicyclic phosphates (
TBPS,
TBPO,
IPTBO)
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BIDN
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Bilobalide
-
Bupropion
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CHEB
-
Chlorophenylsilatrane
-
Cicutoxin
-
Cloflubicyne
-
Cyclothiazide
-
DHEA
-
DHEA-S
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Dieldrin
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(+)-DMBB
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DMCM
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DMPC
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EBOB
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Etbicyphat
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FG-7142 (ZK-31906)
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Fiproles (e.g.,
fipronil)
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Flavonoids (e.g.,
amentoflavone,
oroxylin A)
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Flumazenil
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Fluoroquinolones (e.g.,
ciprofloxacin)
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Flurothyl
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Furosemide
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Golexanolone
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Iomazenil (123I)
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IPTBO
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Isopregnanolone (sepranolone)
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L-655,708
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Laudanosine
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Lindane
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MaxiPost
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Morphine
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Morphine-3-glucuronide
-
MRK-016
-
Naloxone
-
Naltrexone
-
Nicardipine
-
Nonsteroidal antiandrogens (e.g.,
apalutamide,
bicalutamide,
enzalutamide,
flutamide,
nilutamide)
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Oenanthotoxin
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Pentylenetetrazol (pentetrazol)
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Phenylsilatrane
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Picrotoxin (i.e.,
picrotin,
picrotoxinin and
dihydropicrotoxinin)
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Pregnenolone sulfate
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Propybicyphat
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PWZ-029
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Radequinil
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Ro 15-4513
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Ro 19-4603
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RO4882224
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RO4938581
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Sarmazenil
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SCS
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Suritozole
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TB-21007
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TBOB
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TBPS
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TCS-1105
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Terbequinil
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TETS
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Thujone
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U-93631
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Zinc
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ZK-93426
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GABAA-ρTooltip γ-Aminobutyric acid A-rho receptor | |
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Metabotropic |
GABABTooltip γ-Aminobutyric acid B receptor | |
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