1952 Gemonil was introduced by Abbott Laboratories.
1990 Abbott stopped marketing.
Synthesis
Metharbital can be synthesized from 2,2-diethylmalonic acid and O-methylisourea.[5][6][2]
References
^"Metharbital". The Comparative Toxicogenomics Database.
^
abUS 782742, Fischer E, "Trisubstituted barbituric acids and process of making them.", issued 14 February 1905, assigned to E. Merck
^Shorvon SR, Fish DR, Perucca E, Dodson WE, eds. (2004). The Treatment of Epilepsy (2nd ed.). Blackwell.
ISBN0-632-06046-8.
^Resor SR (1991). The Medical Treatment of Epilepsy. Marcel Dekker.
ISBN0-8247-8549-5.
^Halpern A, Jones JW (June 1949). "The characterization of the trialkylbarbiturates". Journal of the American Pharmaceutical Association. 38 (6): 352–5.
doi:
10.1002/jps.3030380619.
PMID18151714.
^Snyder JA, Link KP (1953). "Preparation and Characterization by Alkaline Methanolysis of 5,5-Diethyl-4-(tetraacetyl-β-D-glucosyloxy)-2,6(1,5)-pyrimidinedione". Journal of the American Chemical Society. 75 (8): 1881–1883.
doi:
10.1021/ja01104a030.
1952 Gemonil was introduced by Abbott Laboratories.
1990 Abbott stopped marketing.
Synthesis
Metharbital can be synthesized from 2,2-diethylmalonic acid and O-methylisourea.[5][6][2]
References
^"Metharbital". The Comparative Toxicogenomics Database.
^
abUS 782742, Fischer E, "Trisubstituted barbituric acids and process of making them.", issued 14 February 1905, assigned to E. Merck
^Shorvon SR, Fish DR, Perucca E, Dodson WE, eds. (2004). The Treatment of Epilepsy (2nd ed.). Blackwell.
ISBN0-632-06046-8.
^Resor SR (1991). The Medical Treatment of Epilepsy. Marcel Dekker.
ISBN0-8247-8549-5.
^Halpern A, Jones JW (June 1949). "The characterization of the trialkylbarbiturates". Journal of the American Pharmaceutical Association. 38 (6): 352–5.
doi:
10.1002/jps.3030380619.
PMID18151714.
^Snyder JA, Link KP (1953). "Preparation and Characterization by Alkaline Methanolysis of 5,5-Diethyl-4-(tetraacetyl-β-D-glucosyloxy)-2,6(1,5)-pyrimidinedione". Journal of the American Chemical Society. 75 (8): 1881–1883.
doi:
10.1021/ja01104a030.