The flavonoid has been shown to inhibit certain types of
lipoxygenases[12] and act as an
anti-inflammatory agent.[13] It has antiproliferative effects on ET-1-induced proliferation of pulmonary artery smooth muscle cell proliferation via inhibition of TRPC1 channel expression.[14] Possible antidepressant effects have also been attributed to baicalein in animal research.[15]
^Wang H, Hui KM, Xu S, Chen Y, Wong JT, Xue H (December 2002). "Two flavones from Scutellaria baicalensis Georgi and their binding affinities to the benzodiazepine site of the GABAA receptor complex". Die Pharmazie. 57 (12): 857–858.
PMID12561253.
^Hui KM, Wang XH, Xue H (February 2000). "Interaction of flavones from the roots of Scutellaria baicalensis with the benzodiazepine site". Planta Medica. 66 (1): 91–93.
doi:
10.1055/s-0029-1243121.
PMID10705749.
S2CID260249283.
^Roberts AA (2004). "Testing efficacy of natural anxiolytic compounds". In Cooper EL, Yamaguchi N (eds.). Complementary and Alternative Approaches to Biomedicine. Advances in Experimental Medicine and Biology. Vol. 546. pp. 181–191.
doi:
10.1007/978-1-4757-4820-8_13.
ISBN978-1-4419-3441-3.
PMID15584374.
^
abde Carvalho RS, Duarte FS, de Lima TC (August 2011). "Involvement of GABAergic non-benzodiazepine sites in the anxiolytic-like and sedative effects of the flavonoid baicalein in mice". Behavioural Brain Research. 221 (1): 75–82.
doi:
10.1016/j.bbr.2011.02.038.
PMID21377498.
S2CID45903577.
^Liao JF, Hung WY, Chen CF (March 2003). "Anxiolytic-like effects of baicalein and baicalin in the Vogel conflict test in mice". European Journal of Pharmacology. 464 (2–3): 141–146.
doi:
10.1016/s0014-2999(03)01422-5.
PMID12620506.
^Awad R, Arnason JT, Trudeau V, Bergeron C, Budzinski JW, Foster BC, Merali Z (November 2003). "Phytochemical and biological analysis of skullcap (Scutellaria lateriflora L.): a medicinal plant with anxiolytic properties". Phytomedicine. 10 (8): 640–649.
doi:
10.1078/0944-7113-00374.
PMID14692724.
^Tarragó T, Kichik N, Claasen B, Prades R, Teixidó M, Giralt E (August 2008). "Baicalin, a prodrug able to reach the CNS, is a prolyl oligopeptidase inhibitor". Bioorganic & Medicinal Chemistry. 16 (15): 7516–7524.
doi:
10.1016/j.bmc.2008.04.067.
PMID18650094.
The flavonoid has been shown to inhibit certain types of
lipoxygenases[12] and act as an
anti-inflammatory agent.[13] It has antiproliferative effects on ET-1-induced proliferation of pulmonary artery smooth muscle cell proliferation via inhibition of TRPC1 channel expression.[14] Possible antidepressant effects have also been attributed to baicalein in animal research.[15]
^Wang H, Hui KM, Xu S, Chen Y, Wong JT, Xue H (December 2002). "Two flavones from Scutellaria baicalensis Georgi and their binding affinities to the benzodiazepine site of the GABAA receptor complex". Die Pharmazie. 57 (12): 857–858.
PMID12561253.
^Hui KM, Wang XH, Xue H (February 2000). "Interaction of flavones from the roots of Scutellaria baicalensis with the benzodiazepine site". Planta Medica. 66 (1): 91–93.
doi:
10.1055/s-0029-1243121.
PMID10705749.
S2CID260249283.
^Roberts AA (2004). "Testing efficacy of natural anxiolytic compounds". In Cooper EL, Yamaguchi N (eds.). Complementary and Alternative Approaches to Biomedicine. Advances in Experimental Medicine and Biology. Vol. 546. pp. 181–191.
doi:
10.1007/978-1-4757-4820-8_13.
ISBN978-1-4419-3441-3.
PMID15584374.
^
abde Carvalho RS, Duarte FS, de Lima TC (August 2011). "Involvement of GABAergic non-benzodiazepine sites in the anxiolytic-like and sedative effects of the flavonoid baicalein in mice". Behavioural Brain Research. 221 (1): 75–82.
doi:
10.1016/j.bbr.2011.02.038.
PMID21377498.
S2CID45903577.
^Liao JF, Hung WY, Chen CF (March 2003). "Anxiolytic-like effects of baicalein and baicalin in the Vogel conflict test in mice". European Journal of Pharmacology. 464 (2–3): 141–146.
doi:
10.1016/s0014-2999(03)01422-5.
PMID12620506.
^Awad R, Arnason JT, Trudeau V, Bergeron C, Budzinski JW, Foster BC, Merali Z (November 2003). "Phytochemical and biological analysis of skullcap (Scutellaria lateriflora L.): a medicinal plant with anxiolytic properties". Phytomedicine. 10 (8): 640–649.
doi:
10.1078/0944-7113-00374.
PMID14692724.
^Tarragó T, Kichik N, Claasen B, Prades R, Teixidó M, Giralt E (August 2008). "Baicalin, a prodrug able to reach the CNS, is a prolyl oligopeptidase inhibitor". Bioorganic & Medicinal Chemistry. 16 (15): 7516–7524.
doi:
10.1016/j.bmc.2008.04.067.
PMID18650094.