Identifiers | |
---|---|
| |
CAS Number | |
PubChem CID | |
ChemSpider | |
UNII | |
Chemical and physical data | |
Formula | C15H16N4O2 |
Molar mass | 284.319 g·mol−1 |
3D model ( JSmol) | |
| |
| |
(what is this?) (verify) |
Zomebazam [1] produced by Hoechst is a pyrazolodiazepinone derivative drug with anxiolytic properties. It is structurally related to razobazam and zometapine. [2]
The catalytic hydrogenation of N,2,5-trimethyl-4-phenyldiazenylpyrazol-3-amine [a] (1) over Raney nickel gives 4-amino-1,3-dimethyl-5-methylaminopyrazole [b] (2). Treatment with methyl malonyl chloride [c] (3) gives 4-α-ethoxycarbonylacetylamino-1,3-dimethyl-5-methylaminopyrazole [d] (4). Base-catalyzed lactamization gives (5). The Goldberg reaction completes the synthesis of zomebazam (6). [3] [4]
Identifiers | |
---|---|
| |
CAS Number | |
PubChem CID | |
ChemSpider | |
UNII | |
Chemical and physical data | |
Formula | C15H16N4O2 |
Molar mass | 284.319 g·mol−1 |
3D model ( JSmol) | |
| |
| |
(what is this?) (verify) |
Zomebazam [1] produced by Hoechst is a pyrazolodiazepinone derivative drug with anxiolytic properties. It is structurally related to razobazam and zometapine. [2]
The catalytic hydrogenation of N,2,5-trimethyl-4-phenyldiazenylpyrazol-3-amine [a] (1) over Raney nickel gives 4-amino-1,3-dimethyl-5-methylaminopyrazole [b] (2). Treatment with methyl malonyl chloride [c] (3) gives 4-α-ethoxycarbonylacetylamino-1,3-dimethyl-5-methylaminopyrazole [d] (4). Base-catalyzed lactamization gives (5). The Goldberg reaction completes the synthesis of zomebazam (6). [3] [4]