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Tetrabamate
Combination of
Febarbamate Carbamate, barbiturate
Difebarbamate Carbamate, barbiturate
Phenobarbital Barbiturate
Identifiers
ChEMBL

Tetrabamate (Atrium, G Tril, Sevrium) is a combination drug formulation of febarbamate, difebarbamate, and phenobarbital which was marketed in France and Spain and was used to treat anxiety and alcohol withdrawal-associated muscle tremors, agitation, and depression. [1] [2] [3] [4] It was largely, but not completely discontinued on April 4, 1997, after over 30 years of use due to reports of hepatitis and acute liver failure. [3] [4] [5] [6] The decision to restrict the use of the drug had been long-awaited.[ clarification needed] [6]

References

  1. ^ Index nominum 2000: international drug directory. Taylor & Francis US. 2000. pp. 333 & 427. ISBN  978-3-88763-075-1. Retrieved 26 November 2011.
  2. ^ Chitturi S, Farrell GC (19 October 2011). "Drug-Induced Liver Disease". In Schiff ER, Maddrey WC, Sorrell MF (eds.). Schiff's Diseases of the Liver. John Wiley and Sons. pp. 703–783. doi: 10.1002/9781119950509.ch27. ISBN  978-1-119-95048-6. Retrieved 26 November 2011.
  3. ^ a b Binder D, Jost R, Flury R, Salomon F (May 1995). "[Acute liver failure following tetrabamate]". Schweizerische Medizinische Wochenschrift (in German). 125 (19): 965–969. PMID  7761807.
  4. ^ a b Consolidated list of products whose consumption and/or sale have been banned, withdrawn, severely restricted or not approved by governments. United Nations Publications. 2003. p. 259. ISBN  978-92-1-130230-1. Retrieved 26 November 2011.[ permanent dead link]
  5. ^ Horsmans Y, Lannes D, Pessayre D, Larrey D (December 1994). "Possible association between poor metabolism of mephenytoin and hepatotoxicity caused by Atrium, a fixed combination preparation containing phenobarbital, febarbamate and difebarbamate". Journal of Hepatology. 21 (6): 1075–1079. doi: 10.1016/s0168-8278(05)80620-8. PMID  7699230.
  6. ^ a b "Severe hepatitis due to Atrium". Prescrire International. 10 (55): 150. October 2001. PMID  11824432.
Retrieved from " https://en.wikipedia.org/?title=Tetrabamate&oldid=1188722888"
From Wikipedia, the free encyclopedia
Tetrabamate
Combination of
Febarbamate Carbamate, barbiturate
Difebarbamate Carbamate, barbiturate
Phenobarbital Barbiturate
Identifiers
ChEMBL

Tetrabamate (Atrium, G Tril, Sevrium) is a combination drug formulation of febarbamate, difebarbamate, and phenobarbital which was marketed in France and Spain and was used to treat anxiety and alcohol withdrawal-associated muscle tremors, agitation, and depression. [1] [2] [3] [4] It was largely, but not completely discontinued on April 4, 1997, after over 30 years of use due to reports of hepatitis and acute liver failure. [3] [4] [5] [6] The decision to restrict the use of the drug had been long-awaited.[ clarification needed] [6]

References

  1. ^ Index nominum 2000: international drug directory. Taylor & Francis US. 2000. pp. 333 & 427. ISBN  978-3-88763-075-1. Retrieved 26 November 2011.
  2. ^ Chitturi S, Farrell GC (19 October 2011). "Drug-Induced Liver Disease". In Schiff ER, Maddrey WC, Sorrell MF (eds.). Schiff's Diseases of the Liver. John Wiley and Sons. pp. 703–783. doi: 10.1002/9781119950509.ch27. ISBN  978-1-119-95048-6. Retrieved 26 November 2011.
  3. ^ a b Binder D, Jost R, Flury R, Salomon F (May 1995). "[Acute liver failure following tetrabamate]". Schweizerische Medizinische Wochenschrift (in German). 125 (19): 965–969. PMID  7761807.
  4. ^ a b Consolidated list of products whose consumption and/or sale have been banned, withdrawn, severely restricted or not approved by governments. United Nations Publications. 2003. p. 259. ISBN  978-92-1-130230-1. Retrieved 26 November 2011.[ permanent dead link]
  5. ^ Horsmans Y, Lannes D, Pessayre D, Larrey D (December 1994). "Possible association between poor metabolism of mephenytoin and hepatotoxicity caused by Atrium, a fixed combination preparation containing phenobarbital, febarbamate and difebarbamate". Journal of Hepatology. 21 (6): 1075–1079. doi: 10.1016/s0168-8278(05)80620-8. PMID  7699230.
  6. ^ a b "Severe hepatitis due to Atrium". Prescrire International. 10 (55): 150. October 2001. PMID  11824432.
Retrieved from " https://en.wikipedia.org/?title=Tetrabamate&oldid=1188722888"

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