Clinical data | |
---|---|
Other names | CO-134444; Co 134444; V-134444; 3β-Hydroxy-21-(1H-imidazol-1-yl)-3α-(methoxymethyl)-5α-pregnan-20-one |
Identifiers | |
| |
CAS Number | |
PubChem CID | |
ChemSpider | |
UNII | |
Chemical and physical data | |
Formula | C26H40N2O3 |
Molar mass | 428.617 g·mol−1 |
3D model ( JSmol) | |
| |
|
Posovolone (developmental code name Co 134444) is a synthetic neurosteroid which was under development as a sedative/ hypnotic medication for the treatment of insomnia. [1] [2] [3] [4] It is orally active and acts as a GABAA receptor positive allosteric modulator. [1] [5] [2] In animals, posovolone shows anticonvulsant, anxiolytic-like, ataxic, and sleep-promoting effects and appeared to produce effects similar to those of pregnanolone. [2] [6] Development of the agent was started by 1999 and appears to have been discontinued by 2007. [1] [6] In 2021, an INN was registered for posovolone with the descriptor of " antidepressant". [5] Posovolone was originally developed by Purdue Pharma. [1]
Clinical data | |
---|---|
Other names | CO-134444; Co 134444; V-134444; 3β-Hydroxy-21-(1H-imidazol-1-yl)-3α-(methoxymethyl)-5α-pregnan-20-one |
Identifiers | |
| |
CAS Number | |
PubChem CID | |
ChemSpider | |
UNII | |
Chemical and physical data | |
Formula | C26H40N2O3 |
Molar mass | 428.617 g·mol−1 |
3D model ( JSmol) | |
| |
|
Posovolone (developmental code name Co 134444) is a synthetic neurosteroid which was under development as a sedative/ hypnotic medication for the treatment of insomnia. [1] [2] [3] [4] It is orally active and acts as a GABAA receptor positive allosteric modulator. [1] [5] [2] In animals, posovolone shows anticonvulsant, anxiolytic-like, ataxic, and sleep-promoting effects and appeared to produce effects similar to those of pregnanolone. [2] [6] Development of the agent was started by 1999 and appears to have been discontinued by 2007. [1] [6] In 2021, an INN was registered for posovolone with the descriptor of " antidepressant". [5] Posovolone was originally developed by Purdue Pharma. [1]