The
MAPEG (Membrane-Associated Proteins in Eicosanoid and Glutathione metabolism) family includes a number of human proteins, several of which are involved the production of
leukotrienes. This gene encodes an enzyme that catalyzes the first step in the biosynthesis of
cysteinyl leukotrienes, potent biological compounds derived from
arachidonic acid. Leukotrienes have been implicated as mediators of
anaphylaxis and inflammatory conditions such as human
bronchial asthma. This protein localizes to the
nuclear envelope and adjacent
endoplasmic reticulum.[6]
Penrose JF, Austen KF (2000). "The biochemical, molecular, and genomic aspects of leukotriene C4 synthase". Proc. Assoc. Am. Physicians. 111 (6): 537–46.
doi:
10.1046/j.1525-1381.1999.99212.x.
PMID10591082.
Jakobsson PJ, Morgenstern R, Mancini J, et al. (2000). "Membrane-associated proteins in eicosanoid and glutathione metabolism (MAPEG). A widespread protein superfamily". Am. J. Respir. Crit. Care Med. 161 (2 Pt 2): S20–4.
doi:
10.1164/ajrccm.161.supplement_1.ltta-5.
PMID10673221.
Bigby TD (2000). "The leukotriene C(4) synthase gene and asthma". Am. J. Respir. Cell Mol. Biol. 23 (3): 273–6.
doi:
10.1165/ajrcmb.23.3.f197.
PMID10970815.
Penrose JF, Spector J, Lam BK, et al. (1995). "Purification of human lung leukotriene C4 synthase and preparation of a polyclonal antibody". Am. J. Respir. Crit. Care Med. 152 (1): 283–9.
doi:
10.1164/ajrccm.152.1.7599836.
PMID7599836.
Söderström M, Morgenstern R, Hammarström S (1995). "Protein-protein interaction affinity chromatography of leukotriene C4 synthase". Protein Expr. Purif. 6 (3): 352–6.
doi:
10.1006/prep.1995.1046.
PMID7663172.
The
MAPEG (Membrane-Associated Proteins in Eicosanoid and Glutathione metabolism) family includes a number of human proteins, several of which are involved the production of
leukotrienes. This gene encodes an enzyme that catalyzes the first step in the biosynthesis of
cysteinyl leukotrienes, potent biological compounds derived from
arachidonic acid. Leukotrienes have been implicated as mediators of
anaphylaxis and inflammatory conditions such as human
bronchial asthma. This protein localizes to the
nuclear envelope and adjacent
endoplasmic reticulum.[6]
Penrose JF, Austen KF (2000). "The biochemical, molecular, and genomic aspects of leukotriene C4 synthase". Proc. Assoc. Am. Physicians. 111 (6): 537–46.
doi:
10.1046/j.1525-1381.1999.99212.x.
PMID10591082.
Jakobsson PJ, Morgenstern R, Mancini J, et al. (2000). "Membrane-associated proteins in eicosanoid and glutathione metabolism (MAPEG). A widespread protein superfamily". Am. J. Respir. Crit. Care Med. 161 (2 Pt 2): S20–4.
doi:
10.1164/ajrccm.161.supplement_1.ltta-5.
PMID10673221.
Bigby TD (2000). "The leukotriene C(4) synthase gene and asthma". Am. J. Respir. Cell Mol. Biol. 23 (3): 273–6.
doi:
10.1165/ajrcmb.23.3.f197.
PMID10970815.
Penrose JF, Spector J, Lam BK, et al. (1995). "Purification of human lung leukotriene C4 synthase and preparation of a polyclonal antibody". Am. J. Respir. Crit. Care Med. 152 (1): 283–9.
doi:
10.1164/ajrccm.152.1.7599836.
PMID7599836.
Söderström M, Morgenstern R, Hammarström S (1995). "Protein-protein interaction affinity chromatography of leukotriene C4 synthase". Protein Expr. Purif. 6 (3): 352–6.
doi:
10.1006/prep.1995.1046.
PMID7663172.