From Wikipedia, the free encyclopedia
Chemical compound
Radequinil
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ATC code | |
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5-(3-methoxyphenyl)-3-(5-methyl-1,2,4-oxadiazol-3-yl)-1,6-naphthyridin-2(1H)-one
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CAS Number | |
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PubChem
CID | |
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ChemSpider | |
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UNII | |
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CompTox Dashboard (
EPA) | |
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Formula | C18H14N4O3 |
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Molar mass | 334.335 g·mol−1 |
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3D model (
JSmol) | |
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COc1cccc(c1)c3nccc2NC(=O)\C(=C/c23)c4nc(C)on4
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InChI=1S/C18H14N4O3/c1-10-20-17(22-25-10)14-9-13-15(21-18(14)23)6-7-19-16(13)11-4-3-5-12(8-11)24-2/h3-9H,1-2H3,(H,21,23) Key:JQOFKKWHXGQABB-UHFFFAOYSA-N
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Radequinil (
INN; AC-3933) is a
cognitive enhancer which acts as a partial
inverse agonist of the
benzodiazepine site of the
GABAA receptor.
[1] It was under development by
Dainippon Sumitomo Pharma for the treatment of
Alzheimer's disease and made it to
phase II
clinical trials but development seems to have been halted and it was never marketed.
[1]
[2]
See also
References
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Ionotropic |
GABAATooltip γ-Aminobutyric acid A receptor |
- Positive modulators (abridged; see
here for a full list):
α-EMTBL
-
Alcohols (e.g.,
drinking alcohol,
2M2B)
-
Anabolic steroids
-
Avermectins (e.g.,
ivermectin)
-
Barbiturates (e.g.,
phenobarbital)
-
Benzodiazepines (e.g.,
diazepam)
-
Bromide compounds (e.g.,
potassium bromide)
-
Carbamates (e.g.,
meprobamate)
-
Carbamazepine
-
Chloralose
-
Chlormezanone
-
Clomethiazole
-
Dihydroergolines (e.g.,
ergoloid (dihydroergotoxine))
-
Etazepine
-
Etifoxine
-
Fenamates (e.g.,
mefenamic acid)
-
Flavonoids (e.g.,
apigenin,
hispidulin)
-
Fluoxetine
-
Flupirtine
-
Imidazoles (e.g.,
etomidate)
-
Kava constituents (e.g.,
kavain)
-
Lanthanum
-
Loreclezole
-
Monastrol
-
Neuroactive steroids (e.g.,
allopregnanolone,
cholesterol,
THDOC)
-
Niacin
-
Niacinamide
-
Nonbenzodiazepines (e.g.,
β-carbolines (e.g.,
abecarnil),
cyclopyrrolones (e.g.,
zopiclone),
imidazopyridines (e.g.,
zolpidem),
pyrazolopyrimidines (e.g.,
zaleplon))
-
Norfluoxetine
-
Petrichloral
-
Phenols (e.g.,
propofol)
-
Phenytoin
-
Piperidinediones (e.g.,
glutethimide)
-
Propanidid
-
Pyrazolopyridines (e.g.,
etazolate)
-
Quinazolinones (e.g.,
methaqualone)
-
Retigabine (ezogabine)
-
ROD-188
-
Skullcap constituents (e.g.,
baicalin)
-
Stiripentol
-
Sulfonylalkanes (e.g.,
sulfonmethane (sulfonal))
-
Topiramate
-
Valerian constituents (e.g.,
valerenic acid)
-
Volatiles/
gases (e.g.,
chloral hydrate,
chloroform,
diethyl ether,
paraldehyde,
sevoflurane)
- Negative modulators:
1,3M1B
-
3M2B
-
11-Ketoprogesterone
-
17-Phenylandrostenol
-
α3IA
-
α5IA (LS-193,268)
-
β-CCB
-
β-CCE
-
β-CCM
-
β-CCP
-
β-EMGBL
-
Anabolic steroids
-
Amiloride
-
Anisatin
-
β-Lactams (e.g.,
penicillins,
cephalosporins,
carbapenems)
-
Basmisanil
-
Bemegride
-
Bicyclic phosphates (
TBPS,
TBPO,
IPTBO)
-
BIDN
-
Bilobalide
-
Bupropion
-
CHEB
-
Chlorophenylsilatrane
-
Cicutoxin
-
Cloflubicyne
-
Cyclothiazide
-
DHEA
-
DHEA-S
-
Dieldrin
-
(+)-DMBB
-
DMCM
-
DMPC
-
EBOB
-
Etbicyphat
-
FG-7142 (ZK-31906)
-
Fiproles (e.g.,
fipronil)
-
Flavonoids (e.g.,
amentoflavone,
oroxylin A)
-
Flumazenil
-
Fluoroquinolones (e.g.,
ciprofloxacin)
-
Flurothyl
-
Furosemide
-
Golexanolone
-
Iomazenil (123I)
-
IPTBO
-
Isopregnanolone (sepranolone)
-
L-655,708
-
Laudanosine
-
Lindane
-
MaxiPost
-
Morphine
-
Morphine-3-glucuronide
-
MRK-016
-
Naloxone
-
Naltrexone
-
Nicardipine
-
Nonsteroidal antiandrogens (e.g.,
apalutamide,
bicalutamide,
enzalutamide,
flutamide,
nilutamide)
-
Oenanthotoxin
-
Pentylenetetrazol (pentetrazol)
-
Phenylsilatrane
-
Picrotoxin (i.e.,
picrotin,
picrotoxinin and
dihydropicrotoxinin)
-
Pregnenolone sulfate
-
Propybicyphat
-
PWZ-029
-
Radequinil
-
Ro 15-4513
-
Ro 19-4603
-
RO4882224
-
RO4938581
-
Sarmazenil
-
SCS
-
Suritozole
-
TB-21007
-
TBOB
-
TBPS
-
TCS-1105
-
Terbequinil
-
TETS
-
Thujone
-
U-93631
-
Zinc
-
ZK-93426
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GABAA-ρTooltip γ-Aminobutyric acid A-rho receptor | |
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Metabotropic |
GABABTooltip γ-Aminobutyric acid B receptor | |
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