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Names | |
---|---|
Preferred IUPAC name
N-(4-Nitrophenyl)-N′-[(pyridin-3-yl)methyl]urea | |
Other names
Pyriminil
Vacor | |
Identifiers | |
3D model (
JSmol)
|
|
ChemSpider | |
ECHA InfoCard | 100.053.279 |
PubChem
CID
|
|
UNII | |
CompTox Dashboard (
EPA)
|
|
| |
| |
Properties | |
C13H12N4O3 | |
Molar mass | 272.264 g·mol−1 |
Hazards | |
Occupational safety and health (OHS/OSH): | |
Main hazards
|
Toxic |
Except where otherwise noted, data are given for materials in their
standard state (at 25 °C [77 °F], 100 kPa).
|
Pyrinuron (Pyriminil, Vacor) is a chemical compound formerly used as a rodenticide. [1] Commercial distribution was voluntarily suspended in 1979 and it is not approved by the Environmental Protection Agency for use in the United States. [2] If it is ingested by humans in high doses, it may selectively destroy insulin-producing beta cells in the pancreas causing type 1 diabetes. [2] The neurodegeneration associated with Vacor is caused by its conversion to Vacor-mononucleotide (VMN) by NAMPT and VMN's subsequent activation of the NADase SARM1. [3]
![]() | |
Names | |
---|---|
Preferred IUPAC name
N-(4-Nitrophenyl)-N′-[(pyridin-3-yl)methyl]urea | |
Other names
Pyriminil
Vacor | |
Identifiers | |
3D model (
JSmol)
|
|
ChemSpider | |
ECHA InfoCard | 100.053.279 |
PubChem
CID
|
|
UNII | |
CompTox Dashboard (
EPA)
|
|
| |
| |
Properties | |
C13H12N4O3 | |
Molar mass | 272.264 g·mol−1 |
Hazards | |
Occupational safety and health (OHS/OSH): | |
Main hazards
|
Toxic |
Except where otherwise noted, data are given for materials in their
standard state (at 25 °C [77 °F], 100 kPa).
|
Pyrinuron (Pyriminil, Vacor) is a chemical compound formerly used as a rodenticide. [1] Commercial distribution was voluntarily suspended in 1979 and it is not approved by the Environmental Protection Agency for use in the United States. [2] If it is ingested by humans in high doses, it may selectively destroy insulin-producing beta cells in the pancreas causing type 1 diabetes. [2] The neurodegeneration associated with Vacor is caused by its conversion to Vacor-mononucleotide (VMN) by NAMPT and VMN's subsequent activation of the NADase SARM1. [3]