Bemesetron (MDL-72222) is a
drug which acts as an
antagonist at the
5HT3receptor.[1] It has
antiemetic effects comparable to
metoclopramide,[2] however it is not used clinically, instead its main application is in scientific research studying the involvement of the 5HT3 receptor in the actions of drugs of abuse.[3][4][5][6]
^Shearman GT, Tolcsvai L (1987). "Effect of the selective 5-HT3 receptor antagonists ICS 205-930 and MDL 72222 on 5-HTP-induced head shaking and behavioral symptoms induced by 5-methoxy-N,N,dimethyltryptamine in rats: comparison with some other 5-HT receptor antagonists". Psychopharmacology. 92 (4): 520–3.
doi:
10.1007/bf00176488.
PMID3114804.
S2CID25814825.
^Homesley HD, Hahne WF, McLees B, et al. (April 1993). "Randomized comparison of the antiemetic efficacy of a serotonin type 3 receptor antagonist (MDL 72,222) with a high-dose metoclopramide regimen". Am. J. Clin. Oncol. 16 (2): 175–9.
doi:
10.1097/00000421-199304000-00020.
PMID8452114.
S2CID11733418.
^McKinzie DL, McBride WJ, Murphy JM, Lumeng L, Li TK (October 2000). "Effects of MDL 72222, a serotonin3 antagonist, on operant responding for ethanol by alcohol-preferring P rats". Alcohol. Clin. Exp. Res. 24 (10): 1500–4.
doi:
10.1111/j.1530-0277.2000.tb04567.x.
PMID11045857.
^Kankaanpää A, Meririnne E, Seppälä T (February 2002). "5-HT3 receptor antagonist MDL 72222 attenuates cocaine- and mazindol-, but not methylphenidate-induced neurochemical and behavioral effects in the rat". Psychopharmacology. 159 (4): 341–50.
doi:
10.1007/s00213-001-0939-4.
PMID11823886.
S2CID21614467.
^Kos T, Popik P, Pietraszek M, et al. (May 2006). "Effect of 5-HT3 receptor antagonist MDL 72222 on behaviors induced by ketamine in rats and mice". Eur Neuropsychopharmacol. 16 (4): 297–310.
doi:
10.1016/j.euroneuro.2005.10.001.
PMID16288851.
S2CID43575963.
^Yoo JH, Nam YS, Lee SY, Jang CG (January 2008). "Dopamine neurotransmission is involved in the attenuating effects of 5-HT3 receptor antagonist MDL 72222 on acute methamphetamine-induced locomotor hyperactivity in mice". Synapse. 62 (1): 8–13.
doi:
10.1002/syn.20461.
PMID17948891.
S2CID20699645.
Bemesetron (MDL-72222) is a
drug which acts as an
antagonist at the
5HT3receptor.[1] It has
antiemetic effects comparable to
metoclopramide,[2] however it is not used clinically, instead its main application is in scientific research studying the involvement of the 5HT3 receptor in the actions of drugs of abuse.[3][4][5][6]
^Shearman GT, Tolcsvai L (1987). "Effect of the selective 5-HT3 receptor antagonists ICS 205-930 and MDL 72222 on 5-HTP-induced head shaking and behavioral symptoms induced by 5-methoxy-N,N,dimethyltryptamine in rats: comparison with some other 5-HT receptor antagonists". Psychopharmacology. 92 (4): 520–3.
doi:
10.1007/bf00176488.
PMID3114804.
S2CID25814825.
^Homesley HD, Hahne WF, McLees B, et al. (April 1993). "Randomized comparison of the antiemetic efficacy of a serotonin type 3 receptor antagonist (MDL 72,222) with a high-dose metoclopramide regimen". Am. J. Clin. Oncol. 16 (2): 175–9.
doi:
10.1097/00000421-199304000-00020.
PMID8452114.
S2CID11733418.
^McKinzie DL, McBride WJ, Murphy JM, Lumeng L, Li TK (October 2000). "Effects of MDL 72222, a serotonin3 antagonist, on operant responding for ethanol by alcohol-preferring P rats". Alcohol. Clin. Exp. Res. 24 (10): 1500–4.
doi:
10.1111/j.1530-0277.2000.tb04567.x.
PMID11045857.
^Kankaanpää A, Meririnne E, Seppälä T (February 2002). "5-HT3 receptor antagonist MDL 72222 attenuates cocaine- and mazindol-, but not methylphenidate-induced neurochemical and behavioral effects in the rat". Psychopharmacology. 159 (4): 341–50.
doi:
10.1007/s00213-001-0939-4.
PMID11823886.
S2CID21614467.
^Kos T, Popik P, Pietraszek M, et al. (May 2006). "Effect of 5-HT3 receptor antagonist MDL 72222 on behaviors induced by ketamine in rats and mice". Eur Neuropsychopharmacol. 16 (4): 297–310.
doi:
10.1016/j.euroneuro.2005.10.001.
PMID16288851.
S2CID43575963.
^Yoo JH, Nam YS, Lee SY, Jang CG (January 2008). "Dopamine neurotransmission is involved in the attenuating effects of 5-HT3 receptor antagonist MDL 72222 on acute methamphetamine-induced locomotor hyperactivity in mice". Synapse. 62 (1): 8–13.
doi:
10.1002/syn.20461.
PMID17948891.
S2CID20699645.