AL-37350A

AL-37350A
Identifiers
	IUPAC name (S)-(+)-1-(2-Aminopropyl)-8,9-dihydropyrano[3,2-e]indole;
CAS Number	362603-40-5 ;
PubChem CID	10331436;
IUPHAR/BPS	160;
ChemSpider	8506896 ;
UNII	KT54N4CC67;
ChEMBL	ChEMBL133455 ;
CompTox Dashboard ( EPA)	DTXSID10438239 ;
Chemical and physical data
Formula	C14H18N2O
Molar mass	230.311 g·mol−1
3D model ( JSmol)	Interactive image;
	SMILES O2c1ccc3c(c1CCC2)c(c[nH]3)C[C@@H](N)C;
	InChI InChI=1S/C14H18N2O/c1-9(15)7-10-8-16-12-4-5-13-11(14(10)12)3-2-6-17-13/h4-5,8-9,16H,2-3,6-7,15H2,1H3/t9-/m0/s1 ; Key:VVHJUSGIUWQPIT-VIFPVBQESA-N ;
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AL-37350A (4,5-DHP-AMT) is a tricyclic tryptamine derivative which acts as a potent and selective agonist for the serotonin receptor 5-HT_2A, with a Ki of 2.0 nM, and moderate selectivity over the related 5-HT_2B and 5-HT_2C receptors. It has been shown to have ocular hypotensive activity in animal models, suggesting it may be useful for the treatment of glaucoma.^[1]

References

^ May JA, Chen HH, Rusinko A, Lynch VM, Sharif NA, McLaughlin MA (September 2003). "A novel and selective 5-HT2 receptor agonist with ocular hypotensive activity: (S)-(+)-1-(2-aminopropyl)-8,9-dihydropyrano[3,2-e]indole". Journal of Medicinal Chemistry. 46 (19): 4188–95. CiteSeerX 10.1.1.688.6169. doi: 10.1021/jm030205t. PMID 12954071.

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[pmid12954071-1] May JA, Chen HH, Rusinko A, Lynch VM, Sharif NA, McLaughlin MA (September 2003). "A novel and selective 5-HT2 receptor agonist with ocular hypotensive activity: (S)-(+)-1-(2-aminopropyl)-8,9-dihydropyrano[3,2-e]indole". Journal of Medicinal Chemistry. 46 (19): 4188–95. CiteSeerX 10.1.1.688.6169. doi: 10.1021/jm030205t. PMID 12954071.

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Identifiers

IUPAC name (S)-(+)-1-(2-Aminopropyl)-8,9-dihydropyrano[3,2-e]indole
CAS Number	362603-40-5^Y
PubChem CID	10331436
IUPHAR/BPS	160
ChemSpider	8506896^Y
UNII	KT54N4CC67
ChEMBL	ChEMBL133455^Y
CompTox Dashboard ( EPA)	DTXSID10438239
Chemical and physical data
Formula	C₁₄H₁₈N₂O
Molar mass	230.311 g·mol⁻¹
3D model ( JSmol)	Interactive image
SMILES O2c1ccc3c(c1CCC2)c(c[nH]3)C[C@@H](N)C
InChI InChI=1S/C14H18N2O/c1-9(15)7-10-8-16-12-4-5-13-11(14(10)12)3-2-6-17-13/h4-5,8-9,16H,2-3,6-7,15H2,1H3/t9-/m0/s1^Y Key:VVHJUSGIUWQPIT-VIFPVBQESA-N^Y
^NY (what is this?) (verify)