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JTE 7-31
Names
Preferred IUPAC name
2-[2-(4-Hydroxyphenyl)ethyl]-5-methoxy-4-(pentylamino)-2,3-dihydro-1H -isoindol-1-one
Identifiers
ChemSpider
UNII
InChI=1S/C22H28N2O3/c1-3-4-5-13-23-21-19-15-24(14-12-16-6-8-17(25)9-7-16)22(26)18(19)10-11-20(21)27-2/h6-11,23,25H,3-5,12-15H2,1-2H3
Y Key: FMUMUYFMLZGXJR-UHFFFAOYSA-N
Y InChI=1/C22H28N2O3/c1-3-4-5-13-23-21-19-15-24(14-12-16-6-8-17(25)9-7-16)22(26)18(19)10-11-20(21)27-2/h6-11,23,25H,3-5,12-15H2,1-2H3
Key: FMUMUYFMLZGXJR-UHFFFAOYAA
Oc1ccc(cc1)CCN3Cc2c(ccc(OC)c2NCCCCC)C3=O
Properties
C22 H28 N2 O3
Molar mass
368.469 g/mol
Except where otherwise noted, data are given for materials in their
standard state (at 25 °C [77 °F], 100 kPa).
Chemical compound
JTE 7-31 is a selective
cannabinoid receptor agonist invented by
Japan Tobacco .
[1]
[2] It is a reasonably highly selective
CB2 agonist, but still retains appreciable affinity at
CB1 , with a
Ki of 0.088nM at CB2 vs 11nM at CB1 .
[3]
Legality
JTE 7-31 is illegal in
Alabama .
[4]
See also
References
^
WO patent 1997/029079 , Inaba T, Kaya T, Iwamura H, "Novel compounds and pharmaceutical use thereof", granted 1997-14-08
^
US patent 6017919 , Inaba T, Kaya T, Iwamura H, "Compounds and pharmaceutical use thereof", granted 2000-01-25
^ Han S, Zhang FF, Qian HY, Chen LL, Pu JB, Xie X, Chen JZ (March 2015). "Design, syntheses, structure-activity relationships and docking studies of coumarin derivatives as novel selective ligands for the CB2 receptor". European Journal of Medicinal Chemistry . 93 : 16–32.
doi :
10.1016/j.ejmech.2015.01.054 .
PMID
25644673 .
^
"Alabama Senate Bill SB 333: Controlled Substances" (PDF) .
External links
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